Evidence map›Paper›PMID 39049059›Full record

ArticleVeterinary research2024

Recombinant porcine interferon delta 8 inhibits swine acute diarrhoea syndrome coronavirus infection in vitro and in vivo.

Teng Zhang, Jiale Yao, Zhuan Yang, Jucai Wang, Kankan Yang, Lunguang Yao

Erratum issuedAbstract read
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In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Teng ZhangHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, School of Life Science and Agricultural Engineering, Nanyang Normal University, Nanyang, 473000, China.
Jiale YaoHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, School of Life Science and Agricultural Engineering, Nanyang Normal University, Nanyang, 473000, China.
Zhuan YangHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, School of Life Science and Agricultural Engineering, Nanyang Normal University, Nanyang, 473000, China.
Jucai WangCollege of Food and Drug, Luoyang Normal University, Luoyang, 471934, China.
Kankan YangShenzhen Bay Laboratory, Institute of Infectious Diseases, Shenzhen, 518000, Guangdong, China. yangkk@szbl.ac.cn.
Lunguang YaoHenan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, School of Life Science and Agricultural Engineering, Nanyang Normal University, Nanyang, 473000, China. lunguangyao@nynu.edu.cn.ORCID http://orcid.org/0000-0001-8530-5732

Funding

Doctoral Specialty Foundation of Nanyang Normal University No. 2022ZX032-218310Key Scientific Research Projects of Colleges and Universities in Henan Province of China No. 23A230002Scientific and Technological research project of Henan province No. 232102110093
6 · The paper itself

Abstract

Swine acute diarrhoea syndrome coronavirus (SADS-CoV), which originates from zoonotic transmission of bat coronaviruses in the HKU2 lineage, causes severe illness in pigs and carries a high risk of spreading to humans. At present, there are no licenced therapeutics for the treatment of SADS-CoV. In this study, we examined the effectiveness of recombinant porcine interferon delta 8 (IFN-δ8) against SADS-CoV both in vitro and in vivo. In vitro experiments showed that IFN-δ8 inhibited SADS-CoV proliferation in a concentration-dependent manner, with complete inhibition occurring at a concentration of 5 μg/mL. In vivo experiments demonstrated that two 50 μg/kg doses of IFN-δ8 injected intraperitoneally protected piglets against lethal challenge, blocked viral shedding, attenuated intestinal damage, and decreased the viral load in the jejunum and ileum. Further findings suggested that IFN-δ8 inhibited SADS-CoV infection by increasing the expression of IFN-stimulated genes. These results indicate that IFN-δ8 shows promise as a biological macromolecule drug against SADS-CoV infection.

Indexed as

Coronavirus InfectionsRecombinant ProteinsSwine DiseasesAlphacoronavirusAnimalsAntiviral AgentsCoronavirusInterferonsSwineAntiviral AgentsInterferonsRecombinant Proteinsantiviral capabilityin vitro and in vivoporcine interferon delta 8Severe acute diarrhoea syndrome coronavirus

Identifiers

PMID39049059
PMCPMC11270782

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.