ArticleGenome biology2024
The vast majority of somatic mutations in plants are layer-specific.
Article in Genome biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Layer-specific genetic variation unlocks secondary metabolite diversity in long-lived clonal peppermint.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome degradation in plant tissue culture.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A distributive germline restricts the spread of new mutations.bioRxiv : the preprint server for biology · 2026Article
- A complex reciprocal translocation is linked to reduced gamete viability in a loose-bunch grapevine somatic variant.BMC plant biology · 2026Article
- Transcriptome analysis reveals DNA repair-related clues associated with divergent leaf nuclear DNA diversity inFrontiers in plant science · 2026Article
- Branching architecture limits the number of fixed somatic mutations in trees.G3 (Bethesda, Md.) · 2025Article
- Nanorate sequencing reveals theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Spatial variation in the mutation rate within the plant shoot apical meristem.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A single-cell rice atlas integrates multi-species data to reveal cis-regulatory evolution.Nature plants · 2025Article
- Resolving a century-old enigma: potato 'Bolters' originate from instability of the StCDF1.3 allele.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Minimizing detection bias of somatic mutations in a highly heterozygous oak genome.G3 (Bethesda, Md.) · 2025Article
- Harnessing clonal diversity in grapevine: from genomic insights to modern breeding applications.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Mutations mark cell lineages and sectors in flowers of a woody angiosperm.PLoS genetics · 2025Article
- Somatic Evolution of Stem Cell Mutations in Long-Lived Plants.Molecular biology and evolution · 2025Article
- Can Unicellular Organisms Sequester a Germline? The Yeast-Germline Hypothesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Exploring the Relationship Between Gene Expression and Low-Frequency Somatic Mutations in Arabidopsis with Duplex Sequencing.Genome biology and evolution · 2024Article
- The identification and analysis of meristematic mutations within the apple tree that developed the RubyMac sport mutation.BMC plant biology · 2024Article
- The vast majority of somatic mutations in plants are layer-specific.Genome biology · 2024Article
- Investigating low frequency somatic mutations inbioRxiv : the preprint server for biology · 2024Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundPlant meristems are structured organs consisting of distinct layers of stem cells, which differentiate into new plant tissue. Mutations in meristematic layers can propagate into large sectors of the plant. However, the characteristics of meristematic mutations remain unclear, limiting our understanding of the genetic basis of somaclonal phenotypic variation.
resultsHere, we analyse the frequency and distribution of somatic mutations in an apricot tree. We separately sequence the epidermis (developing from meristem layer 1) and the flesh (developing from meristem layer 2) of several fruits sampled across the entire tree. We find that most somatic mutations (> 90%) are specific to individual layers. Interestingly, layer 1 shows a higher mutation load than layer 2, implying different mutational dynamics between the layers. The distribution of somatic mutations follows the branching of the tree. This suggests that somatic mutations are propagated to developing branches through axillary meristems. In turn, this leads us to the unexpected observation that the genomes of layer 1 of distant branches are more similar to each other than to the genomes of layer 2 of the same branches. Finally, using single-cell RNA sequencing, we demonstrate that layer-specific mutations were only transcribed in the cells of the respective layers and can form the genetic basis of somaclonal phenotypic variation.
conclusionsHere, we analyse the frequency and distribution of somatic mutations with meristematic origin. Our observations on the layer specificity of somatic mutations outline how they are distributed, how they propagate, and how they can impact clonally propagated crops.
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