Evidence map›Paper›PMID 39048971›Full record

ArticleBMC ophthalmology2024

Retinal integrity in human babesiosis: a pilot study.

Elyssa Dionne, Ron A Adelman, Osman Cekic, Marjorie Golden, Anne Spichler Moffarah, Peter J Krause, Shelli F Farhadian

Abstract read
In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elyssa DionneYale School of Medicine, 135 College Street, New Haven, CT, 06510, USA.
Ron A AdelmanDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, 40 Temple Street, New Haven, CT, 06510, USA.
Osman CekicDepartment of Ophthalmology and Visual Science, Yale University School of Medicine, 40 Temple Street, New Haven, CT, 06510, USA.
Marjorie GoldenDepartment of Internal Medicine: Infectious Disease, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Anne Spichler MoffarahDepartment of Internal Medicine: Infectious Disease, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Peter J Krause *Department of Internal Medicine: Infectious Disease, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA.
Shelli F Farhadian *Department of Internal Medicine: Infectious Disease, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA. shelli.farhadian@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

backgroundPrior case reports and animal studies have reported on potential ophthalmologic complications of babesiosis, but this issue has not previously been addressed in a cohort of patients with babesiosis. This cross-sectional descriptive pilot study evaluated the retinas of patients with acute babesiosis to determine if retinal abnormalities are a feature of the disease.

methodsWe screened all patients admitted to Yale New Haven Hospital with laboratory confirmed babesiosis during the summer of 2023 and obtained informed consent. Patients were interviewed and underwent pupil dilation and a retinal examination using an indirect ophthalmoscope. Demographic and clinical information were obtained by questionnaire and through chart review.

resultsTen patients underwent retinal eye exams with results that were generally unremarkable. No study patients showed any signs of retinal inflammation, infection, retinal bleeding, retinal tears, or abnormal vessel formation that could be attributed to infection.

conclusionThis small study did not find evidence of retinopathy in patients with babesiosis. Further studies with larger populations, repeated exams, and long term follow up will further elucidate the potential small vessel complications of human babesiosis.

Indexed as

BabesiosisEye Infections, ParasiticRetinal DiseasesAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPilot ProjectsRetinaBabesiosisPilot studyRetinopathy

Identifiers

PMID39048971
PMCPMC11267664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.