ArticleNature2024
A human autoimmune organoid model reveals IL-7 function in coeliac disease.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed.
- Crosstalk between the microbiota and intestinal γδ T cell compartments in health and IBD.Gut microbes · 2026Review
- Article
- Microphysiological models of human gastrointestinal diseases.Nature biomedical engineering · 2026Review
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- Building and regenerating intestines by manipulating intestinal stem cells.Nature reviews. Gastroenterology & hepatology · 2026Review
- Engineering autoimmune disease models using organoids: Harnessing microenvironmental engineering for precision medicine and immunological recapitulation.Bioengineering & translational medicine · 2026Review
- Shaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from a SIGENP expert groups.JPGN reports · 2026Review
- Human airway organoids for bacterial-host interaction studies: methods, insights and translational promise.Thorax · 2026Review
- Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives.International journal of molecular sciences · 2026Review
- Refractory Celiac Disease: Nutritional Failure, Immune Dysregulation, and Lymphomagenesis.Nutrients · 2026Review
- The application progress of organoid technology in the toxicity assessment of environmental pollutants.Cell biology and toxicology · 2026Review
- Toward Physiologically Relevant Organoid Models of Polycystic Kidney Disease through Microenvironment Reconstruction.Journal of the American Society of Nephrology : JASN · 2026Review
- Construction of TERT Monoallelic Knockout and TERT Overexpression of Porcine Cell Lines and Study of the Cellular Biological Characteristics.Animals : an open access journal from MDPI · 2026Article
- Organoids: technology refining, current applications and future directions.Molecular biomedicine · 2026Review
- Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges.Nature reviews. Drug discovery · 2026Review
- Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection.Research square · 2026Article
- Article
- Modeling Alzheimer's disease with brain organoids: mechanisms, applications, and future directions.Frontiers in cell and developmental biology · 2026Review
- Notch signaling is a driver of glandular stem cell activity and regenerative migration after damage.The EMBO journal · 2026Article
- Long noncoding RNA regulation of immunity.Nature immunology · 2026Review
Corrections and comments
- Commented on by
Authors and funding
31 authors.
António J M SantosDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Vincent van UnenDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9339-8430
Zhongqi LinDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4806-0091
Steven M ChirieleisonDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3997-5652
Nhi HaDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5782-0921
Arpit BatishDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Joshua E ChanDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6016-1397
Jose CedanoDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Elisa T ZhangDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Qinghui MuDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Alexander Guh-SieselDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Madeline TomaskeDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Deana ColburgDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Sushama VarmaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Shannon S ChoiDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Asbjørn ChristophersenK. G. Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ani BaghdasaryanDepartment of Chemistry, Stanford University School of Medicine, Stanford, CA, USA.
Kathryn E YostCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6807-950X
Kasper KarlssonDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Andrew HaDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Jing LiInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Hongjie DaiDepartment of Chemistry, Stanford University School of Medicine, Stanford, CA, USA.
Zachary M SellersDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5352-7760
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9459-4393
James C Y DunnDepartment of Pediatric Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6826-7065
Bing M ZhangDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Elizabeth D MellinsDepartment of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2577-139X
Ludvig M SollidK. G. Jebsen Coeliac Disease Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0001-8860-704X
Nielsen Q Fernandez-BeckerDivision of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6868-657X
Calvin J KuoDivision of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. cjkuo@stanford.edu.ORCID 0000-0002-7427-5985
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MCenter for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MStanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI AMIEVA, MANUEL R, KUO, CALVIN J · 2015 to 2025
$13.5MRegulation of actively proliferating and quiescent intestinal stem cellsU01DK085527 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2009 to 2023
$6.9MOrganoid-based Discovery of Oncogenic Drivers and Treatment Resistance MechanismsU01CA217851 · NCI · STANFORD UNIVERSITY · PI CURTIS, CHRISTINA N, JI, HANLEE P · 2017 to 2021
$4.7MStructure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and TherapyR01DK115728 · NIDDK · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER, KUO, CALVIN J · 2018 to 2022
$3.9MImmunotherapy Modeling in Organoids Co-preserving Tumor and Infiltrating Immune CompartmentsR01CA251514 · NCI · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2021 to 2025
$3.2MIntestinal organoid modeling of SARS-CoV-2-stimulated innate and adaptive immunityR01DK130414 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2021 to 2023
$1.2MNCI NIH HHS R01 CA251514NCI NIH HHS U01 CA217851NHGRI NIH HHS RM1 HG007735NIAID NIH HHS P01 AI153559NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI116484NIDDK NIH HHS R01 DK115728NIDDK NIH HHS R01 DK130414NIDDK NIH HHS U01 DK085527
Abstract
In vitro models of autoimmunity are constrained by an inability to culture affected epithelium alongside the complex tissue-resident immune microenvironment. Coeliac disease (CeD) is an autoimmune disease in which dietary gluten-derived peptides bind to the major histocompatibility complex (MHC) class II human leukocyte antigen molecules (HLA)-DQ2 or HLA-DQ8 to initiate immune-mediated duodenal mucosal injury
Indexed as
Celiac DiseaseDuodenumInterleukin-7Intestinal MucosaModels, BiologicalOrganoidsAutoantibodiesAutoimmunityBiopsyB-LymphocytesEpitopesGlutensGTP-Binding ProteinsHLA-DQ AntigensHumansKiller Cells, NaturalAutoantibodiesEpitopesGlutensGTP-Binding ProteinsHLA-DQ2 antigenHLA-DQ AntigensInterleukin-7KLRC2 protein, humanKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KProtein Glutamine gamma Glutamyltransferase 2Receptors, Antigen, B-CellReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.