Evidence map›Paper›PMID 39048728›Full record

GuidelineSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

MASCC/ISOO Clinical Practice Statement: Management of salivary gland hypofunction and xerostomia in cancer patients.

Catherine Hong, Siri Beier Jensen, Arjan Vissink, Pierluigi Bonomo, Alan Roger Santos-Silva, Luiz Alcino Gueiros, Joel B Epstein, Sharon Elad

Erratum issuedAbstract readPractice GuidelineReview
In one paragraph

Guideline in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Diagnosis and management of immune checkpoint inhibitor-induced dry mouth and salivary gland dysfunction in oncology patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Pooled it
  2. Pooled it
  3. MASCC/ISOO Clinical Practice Statement: management of oral complications of immunotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Guideline
  4. MASCC/ISOO Clinical Practice Statement: Management of oral manifestations of chronic graft-versus-host-disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Guideline
  5. Trial
  6. The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact.Journal of immunotherapy and precision oncology · 2026
    Review
  7. Article
  8. Review
  9. Damage of irradiated teeth by ultrasonic scaling: an in vitro study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  10. Supportive care for talquetamab-related dysgeusia in multiple myeloma: mixed-methods evidence, nutrition-focused flowchart, and digital companion concept.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Optimization of oncological care: proposal for the creation of rehabilitation networks in head and neck oncology.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  17. Article
  18. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Catherine HongDiscipline of Orthodontics and Paediatric Dentistry, Faculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore, 119085, Singapore. denchhl@nus.edu.sg.
Siri Beier JensenDepartment of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Arjan VissinkDepartment of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Pierluigi BonomoDepartment of Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Alan Roger Santos-SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas, Campinas, Brazil.
Luiz Alcino GueirosDepartment of Clinic and Preventive Dentistry, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
Joel B EpsteinDental Oncology Services, City of Hope Duarte, CA and Cedars-Sinai Health System, Los Angeles, CA, USA.
Sharon EladOral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the management of salivary gland hypofunction and xerostomia in cancer patients.

methodsThis CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group of MASCC/ISOO. The information is presented in the form of succinct bullets and tables to generate a short manual about the best standard of care.

resultsSalivary gland hypofunction and xerostomia in cancer patients are managed by (i) stimulating saliva production of salivary glands with residual secretory capacity or (ii) artificial wetting of the oral and lip surfaces which can be achieved by pharmacological or non-pharmacological interventions. Pharmacological interventions encompass the use of sialagogues and sialolytics, while non-pharmacological interventions involve the use of moistening agents, mechanical, gustatory, or electrostimulation of the salivary glands. Additional treatment modalities may be incorporated in practice based on local availability and the clinician's experience.

conclusionThe information presented in this CPS offers clinicians convenient access to the dosages and regimens of different interventions for managing salivary gland hypofunction or xerostomia to facilitate clinical efficiency and conserve valuable time for clinicians.

Indexed as

NeoplasmsXerostomiaHumansSalivary GlandsCancerDry mouthOral manifestationsSalivary gland hypofunctionXerostomia

Identifiers

PMID39048728
PMCPMC11550240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.