Evidence map›Paper›PMID 39048709›Full record

ArticleScientific reports2024

Development and validation of a predictive model based on β-Klotho for head and neck squamous cell carcinoma.

XiangXiu Wang, HongWei Liu, Gang Wu, Yan Lu, Ying Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

XiangXiu Wang *Jinzhou Medical University, Jinzhou, 121000, China.
HongWei Liu *Cancer Hospital of China Medical University, Shenyang, 110042, China.
Gang WuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China.
Yan LuDepartment of Otorhinolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China.
Ying CuiDepartment of Otorhinolaryngology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121000, China. yingwuwu2002@jzmu.edu.cn.

Funding

Department of Science and Technology of Liaoning Province 2023JH2/101300077
6 · The paper itself

Abstract

Head and neck epithelial tissue tumors may be identified as head and neck squamous cell carcinoma (HNSC). Numerous malignancies are encouraged by dysregulation of the FGF19-β-Klotho (KLB) axis in the tumor microenvironment. Using protein databases and RT-qPCR, we examined KLB expression in HNSC. In HNSC, higher KLB expression was linked to longer survival times and better prognoses. Furthermore, variations in drug susceptibility and immunological infiltration were noted according to KLB expression levels. These results underscore the importance of KLB in the course and management of HNSC by indicating that it may function as a possible prognostic marker and influence immunological and therapeutic responses in these individuals. Further study on HNSC is necessary to investigate KLB's potential as a therapeutic target and prognostic indicator.

Indexed as

Head and Neck NeoplasmsKlotho ProteinsSquamous Cell Carcinoma of Head and NeckAgedBiomarkers, TumorCarcinoma, Squamous CellFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorKLB protein, humanKlotho Proteins

Identifiers

PMID39048709
PMCPMC11269606

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.