ArticleScientific reports2024
General instability of dipeptides in concentrated sulfuric acid as relevant for the Venus cloud habitability.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Peptides adopt stable omega-loop structures in concentrated sulfuric acid.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Synthesis of Azatide Dipeptide Analogs and Their Stability and Reactivity in 98%Molecules (Basel, Switzerland) · 2026Article
- Stability and Reactivity of Cyclopentane Nucleoside Analogs in 98%Molecules (Basel, Switzerland) · 2026Article
- Stability and Reactivity of Alternative Nucleobases in Concentrated Sulfuric Acid.Molecules (Basel, Switzerland) · 2026Article
- Warm, water-depleted rocky exoplanets with surface ionic liquids: A proposed class for planetary habitability.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The diversity of exoplanetary environments and the search for signs of life beyond Earth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Astrobiological implications of the stability and reactivity of peptide nucleic acid (PNA) in concentrated sulfuric acid.Science advances · 2025Article
- Article
- On the possibility of carbon-free heteropolymers on Venus: a computational astrobiology study.QRB discovery · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Recent renewed interest in the possibility of life in the acidic clouds of Venus has led to new studies on organic chemistry in concentrated sulfuric acid. We have previously found that the majority of amino acids are stable in the range of Venus' cloud sulfuric acid concentrations (81% and 98% w/w, the rest being water). The natural next question is whether dipeptides, as precursors to larger peptides and proteins, could be stable in this environment. We investigated the reactivity of the peptide bond using 20 homodipeptides and find that the majority of them undergo solvolysis within a few weeks, at both sulfuric acid concentrations. Notably, a few exceptions exist. HH and GG dipeptides are stable in 98% w/w sulfuric acid for at least 4 months, while II, LL, VV, PP, RR and KK resist hydrolysis in 81% w/w sulfuric acid for at least 5 weeks. Moreover, the breakdown process of the dipeptides studied in 98% w/w concentrated sulfuric acid is different from the standard acid-catalyzed hydrolysis that releases monomeric amino acids. Despite a few exceptions at a single concentration, no homodipeptides have demonstrated stability across both acid concentrations studied. This indicates that any hypothetical life on Venus would likely require a functional substitute for the peptide bond that can maintain stability throughout the range of sulfuric acid concentrations present.
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