Evidence map›Paper›PMID 39048597›Full record

ArticleScientific reports2024

Genetic variation in NOTCH1 is associated with overweight and obesity in Brazilian elderly.

Estevão Carlos Silva Barcelos, Michel Satya Naslavsky, Izadora Silveira Fernandes, Marilia Oliveira Scliar, Guilherme Lopes Yamamoto, Jaqueline Yu Ting Wang, Laís Bride, Valdemir Pereira de Sousa, Lucia Helena Sagrillo Pimassoni, Paolo Sportoletti and 6 more

Abstract read
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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Genetic Variants ofGenes · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Estevão Carlos Silva BarcelosPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Michel Satya NaslavskyDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Izadora Silveira FernandesPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Marilia Oliveira ScliarDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Guilherme Lopes YamamotoDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Jaqueline Yu Ting WangHuman Genome and Stem Cell Research Center, University of São Paulo, São Paulo, Brazil.
Laís BridePostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Valdemir Pereira de SousaPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Lucia Helena Sagrillo PimassoniSchool of Sciences of Santa Casa de Misericórdia de Vitória (EMESCAM), Vitória, Espírito Santo, Brazil.
Paolo SportolettiInstitute of Hematology-Centro di Ricerca Emato-Oncologica (CREO), Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Flavia de PaulaPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Sandra Ventorin von ZeidlerPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Yeda Aparecida Oliveira DuarteSchool of Nursing, University of São Paulo, São Paulo, Brazil.
Maria Rita Passos-BuenoDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Mayana ZatzDepartment of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, Brazil.
Flávia Imbroisi Valle ErreraPostgraduate Program in Biotechnology, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil. flavia.valle@ufes.br.

Funding

CAPES 19/2016CNPq-Casadinho-Procad 552672/2011-4FAPES 0123/2016FAPESP/CEPID 08028-1/2013INCT/FAPESP 50931-3/2014
6 · The paper itself

Abstract

Excessive weight (overweight and obesity) is a common disorder involving genetic and environmental factors, associated with cardiovascular diseases, type-2 diabetes, and others. NOTCH1 is critical for the maintenance of stem cells and adult tissues, being reported as a key player in metabolism and adipogenesis in animals. Thus, we test the hypothesis that NOTCH1 Single Nucleotide Polymorphisms (SNPs) are associated with excessive weight. Participants from the census-based cohort SABE (Saúde, Bem Estar e Envelhecimento-Health, Well-Being, and Aging), carried out in the city of São Paulo-Brazil, were stratified into cases and controls according to BMI. We filter the SNPs located at the start and end positions of NOTCH1 and 50 Kb on both sides. We selected SNPs with minor allelic frequency (MAF) greater than or equal to 0.01 and Hardy-Weinberg equilibrium (p > 0.05) and r

Indexed as

ObesityOverweightPolymorphism, Single NucleotideReceptor, Notch1AgedBody Mass IndexBrazilCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHaplotypesHumansMaleMiddle AgedNOTCH1 protein, humanReceptor, Notch1ElderlyExcessive weightHaplotypeNOTCH1 geneSingle nucleotide polymorphism

Identifiers

PMID39048597
PMCPMC11269636

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.