ArticleNature communications2024
Direct synthesis of partially ethoxylated branched polyethylenimine from ethanolamine.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- In-situ recomposition of polyethyleneimine additive enables a multiprocess long-lifetime thermocell.Nature communications · 2026Article
- Synthesis, Spectroscopic Characterization, and Biological Evaluation of a Novel Acyclic Heterocyclic Compound: Anticancer, Antioxidant, Antifungal, and Molecular Docking Studies.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Polyethylenimine Carriers for Drug and Gene Delivery.Polymers · 2025Review
- Rising Opportunities in Catalytic Dehydrogenative Polymerization.ACS catalysis · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We report here a method to make a branched and partially ethoxylated polyethyleneimine derivative directly from ethanolamine. The polymerization reaction is catalysed by a pincer complex of Earth-abundant metal, manganese, and produces water as the only byproduct. Industrial processes to produce polyethyleneimines involve the transformation of ethanolamine to a highly toxic chemical, aziridine, by an energy-intensive/waste-generating process followed by the ring-opening polymerization of aziridine. The reported method bypasses the need to produce a highly toxic intermediate and presents advantages over the current state-of-the-art. We propose that the polymerization process follows a hydrogen borrowing pathway that involves (a) dehydrogenation of ethanolamine to form 2-aminoacetaldehyde, (b) dehydrative coupling of 2-aminoacetaldehyde with ethanolamine to form an imine derivative, and (c) subsequent hydrogenation of imine derivative to form alkylated amines.
Identifiers
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Registered trials
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