Evidence map›Paper›PMID 39048559›Full record

ArticleNature communications2024

Loss-of-function mutations in Keratin 32 gene disrupt skin immune homeostasis in pityriasis rubra pilaris.

Peidian Shi, Wenjie Chen, Xinxing Lyu, Zhenzhen Wang, Wenchao Li, Fengming Jia, Chunzhi Zheng, Tingting Liu, Chuan Wang, Yuan Zhang and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Peidian Shi *Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0002-2081-2634
Wenjie Chen *Hospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0002-8099-9947
Xinxing LyuHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Zhenzhen WangHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0001-5927-2471
Wenchao LiHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Fengming JiaHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Chunzhi ZhengHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Tingting LiuHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Chuan WangHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Yuan ZhangHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Zihao MiHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Yonghu SunHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0003-4553-2871
Xuechao ChenHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Shengli ChenHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Guizhi ZhouHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Yongxia LiuHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Yingjie LinHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Fuxiang BaiHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China.
Qing SunDepartment of Dermatology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Monday O OgeseDepartment of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.ORCID 0000-0002-1873-4032
Qiang YuGenome Institute of Singapore, Singapore, Singapore.ORCID 0000-0003-2132-8278
Jianjun LiuGenome Institute of Singapore, Singapore, Singapore.ORCID 0000-0002-3255-3019
Hong LiuHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China. hongyue2519@hotmail.com.ORCID 0000-0003-4488-0372
Furen ZhangHospital for Skin Diseases, Shandong First Medical University, Jinan, Shandong, China. zhangfuren@hotmail.com.ORCID 0000-0002-3383-1973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pityriasis rubra pilaris (PRP) is an inflammatory papulosquamous dermatosis, characterized by hyperkeratotic follicular papules and erythematous desquamative plaques. The precise pathogenic mechanism underlying PRP remains incompletely understood. Herein, we conduct a case-control study involving a cohort of 102 patients with sporadic PRP and 800 healthy controls of Han Chinese population and identify significant associations (P = 1.73 × 10

Indexed as

KeratinocytesPityriasis Rubra PilarisSkinAdultAnimalsCase-Control StudiesFemaleHomeostasisHumansI-kappa B KinaseKeratinsLoss of Function MutationMaleMiceMice, KnockoutMiddle AgedI-kappa B KinaseKeratinsNF-kappa B

Identifiers

PMID39048559
PMCPMC11269665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.