ArticleNature communications2024
Global, asynchronous partial sweeps at multiple insecticide resistance genes in Aedes mosquitoes.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Emerging and regionally novel voltage-gated sodium channel mutations associated with pyrethroid resistance and altered binding affinity in Aedes albopictus (Skuse) from Northern Peninsular Malaysia.Parasites & vectors · 2026Article
- An Ecological Impact Assessment Framework and Integrated Management Pathway for Large-Scale Chemical Mosquito Control in Urban Areas.ACS environmental Au · 2026Article
- Soft Selective Sweeps Predominate in the Yellow Fever Mosquito Aedes aegypti.Molecular biology and evolution · 2026Article
- Updated Adulticide Susceptibility Status of Florida Populations ofPathogens (Basel, Switzerland) · 2026Article
- Pickpocket315 affects male mating behavior in the yellow fever mosquito Aedes aegypti.G3 (Bethesda, Md.) · 2026Article
- Population genomics reveal multiple independent origins of pesticide resistance in the polyphagous pest, Tetranychus urticae.Communications biology · 2025Article
- Recurrent mutations drive the rapid evolution of pesticide resistance in the two-spotted spider miteeLife · 2025Article
- Genomics of urban adaptation and exaptation in mosquitoes and consequences for vectorial capacity.Current opinion in insect science · 2025Review
- Signatures of soft selective sweeps predominate in the yellow fever mosquitobioRxiv : the preprint server for biology · 2025Article
- Knockdown-resistance (kdr) mutations in Indian Aedes aegypti populations: Lack of recombination among haplotypes bearing V1016G, F1534C, and F1534L kdr alleles.PLoS neglected tropical diseases · 2025Article
- Populations of the Australian Saltmarsh MosquitoEvolutionary applications · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Aedes aegypti (yellow fever mosquito) and Ae. albopictus (Asian tiger mosquito) are globally invasive pests that confer the world's dengue burden. Insecticide-based management has led to the evolution of insecticide resistance in both species, though the genetic architecture and geographical spread of resistance remains incompletely understood. This study investigates partial selective sweeps at resistance genes on two chromosomes and characterises their spread across populations. Sweeps at the voltage-sensitive sodium channel (VSSC) gene on chromosome 3 correspond to one resistance-associated nucleotide substitution in Ae. albopictus and three in Ae. aegypti, including two substitutions at the same nucleotide position (F1534C) that have evolved and spread independently. In Ae. aegypti, we also identify partial sweeps at a second locus on chromosome 2. This locus contains 15 glutathione S-transferase (GST) epsilon class genes with significant copy number variation among populations and where three distinct genetic backgrounds have spread across the Indo-Pacific region, the Americas, and Australia. Local geographical patterns and linkage networks indicate VSSC and GST backgrounds probably spread at different times and interact locally with different genes to produce resistance phenotypes. These findings highlight the rapid global spread of resistance and are evidence for the critical importance of GST genes in resistance evolution.
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