Evidence map›Paper›PMID 39048365›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Fournier's Gangrene in the Course of Treatment of Advanced Hepatocellular Carcinoma with Molecular-targeted Therapy.

Yusuke Komeda, Shinsaku Nagamatsu, Daisuke Kaya, Ayana Sueki, Chisa Yamamoto, Kohei Ohta, Yuya Matsuo, Yuya Nishio, Shoma Kikukawa, Kyohei Matsuura and 3 more

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yusuke KomedaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Shinsaku NagamatsuDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Daisuke KayaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Ayana SuekiDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Chisa YamamotoDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Kohei OhtaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Yuya MatsuoDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Yuya NishioDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Shoma KikukawaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Kyohei MatsuuraDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Hideki MatsuoDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.
Masakazu UejimaDepartment of Endocrinology and Metabolism, Nara Prefecture General Medical Center, Japan.
Kei MoriyaDepartment of Gastroenterology, Nara Prefecture General Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lenvatinib is a molecular-targeted agent with proven efficacy against hepatocellular carcinoma (HCC). We herein report a case of lenvatinib-associated Fournier gangrene. A 66-year-old man with advanced HCC presented with a high fever 4 weeks after switching to lenvatinib. He had severe erythema in the inguinal region, and abdominal computed tomography revealed extensive emphysema and scrotal abscesses. He was diagnosed with Fournier's gangrene, and his symptoms were successfully treated with local debridement and antimicrobial therapy. Although reports of lenvatinib-associated Fournier's gangrene are rare, they should be kept in mind, as the condition could progress rapidly and have poor outcomes.

Indexed as

Antineoplastic AgentsCarcinoma, HepatocellularFournier GangreneLiver NeoplasmsMolecular Targeted TherapyPhenylurea CompoundsQuinolinesAgedDebridementHumansMaleAntineoplastic AgentslenvatinibPhenylurea CompoundsQuinolinesadvanced hepatocellular carcinomaadverse eventbevacizumabFournier's gangrenelenvatinibmolecular targeted agent

Identifiers

PMID39048365
PMCPMC11949679

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.