Evidence map›Paper›PMID 39048319›Full record

ArticleYonsei medical journal2024

Diverging Relationships among Amyloid, Tau, and Brain Atrophy in Early-Onset and Late-Onset Alzheimer's Disease.

Han Kyu Na, Jeong-Hyeon Shin, Sung-Woo Kim, Seongho Seo, Woo-Ram Kim, Jae Myeong Kang, Sang-Yoon Lee, Jaelim Cho, Justin Byun, Nobuyuki Okamura and 2 more

Abstract read
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In one paragraph

Article in Yonsei medical journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Han Kyu Na *Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2093-1641
Jeong-Hyeon Shin *Bio Medical Research Center, Bio Medical & Health Division, Korea Testing Laboratory, Daegu, Korea.ORCID https://orcid.org/0000-0002-8680-256X
Sung-Woo KimSchool of Biomedical Engineering, Korea University, Seoul, Korea.ORCID https://orcid.org/0009-0006-0558-1635
Seongho SeoNeuroscience Research Institute, Gachon University, Incheon, Korea.ORCID https://orcid.org/0000-0001-7894-0535
Woo-Ram KimNeuroscience Research Institute, Gachon University, Incheon, Korea.ORCID https://orcid.org/0000-0003-1361-4426
Jae Myeong KangDepartment of Psychiatry, Gachon University Gil Medical Center, Incheon, Korea.ORCID https://orcid.org/0000-0003-0803-9332
Sang-Yoon LeeDepartment of Neuroscience, College of Medicine, Gachon University, Incheon, Korea.ORCID https://orcid.org/0000-0002-6029-8553
Jaelim ChoDepartment of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4524-0310
Justin ByunDepartment of Rehabilitation Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-7953-8238
Nobuyuki OkamuraDivision of Pharmacology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.ORCID https://orcid.org/0000-0002-5991-7812
Joon-Kyung SeongSchool of Biomedical Engineering, Korea University, Seoul, Korea.ORCID https://orcid.org/0000-0001-8227-5849
Young NohNeuroscience Research Institute, Gachon University, Incheon, Korea.ORCID https://orcid.org/0000-0002-9633-3314

Funding

Gachon University Gil Medical Center FRD2022-16Korea Health Industry Development Institute HI14C1135National Research Foundation of Korea 2021R1A6A1A03038996
6 · The paper itself

Abstract

purposeAlzheimer's disease (AD) dementia may not be a single disease entity. Early-onset AD (EOAD) and late-onset AD (LOAD) have been united under the same eponym of AD until now, but disentangling the heterogeneity according to the age of sonset has been a major tenet in the field of AD research. MATERIALS AND

methodsNinety-nine patients with AD (EOAD, n=54; LOAD, n=45) and 66 cognitively normal controls completed both [

resultsEOAD patients had higher THK retention in the precuneus, parietal, and frontal lobe, while LOAD patients had higher THK retention in the medial temporal lobe. Intravoxel correlation analyses revealed that EOAD presented narrower territory of local FLUTE-THK correlation, while LOAD presented broader territory of correlation extending to overall parieto-occipito-temporal regions. EOAD patients had broader brain areas which showed significant negative correlations between cortical thickness and THK retention, whereas in LOAD, only limited brain areas showed significant correlation with THK retention. In EOAD, most of the cognitive test results were correlated with THK retention. However, a few cognitive test results were correlated with THK retention in LOAD.

conclusionLOAD seemed to show gradual increase in tau and amyloid, and those two pathologies have association to each other. On the other hand, in EOAD, tau and amyloid may develop more abruptly and independently. These findings suggest LOAD and EOAD may have different courses of pathomechanism.

Indexed as

Alzheimer DiseaseAtrophyBrainMagnetic Resonance ImagingPositron-Emission Tomographytau ProteinsAgedAged, 80 and overAge of OnsetAminopyridinesAmyloidAniline CompoundsBenzothiazolesFemaleHumansMaleAminopyridinesAmyloidAniline CompoundsBenzothiazolesflutemetamolMAPT protein, humanQuinolinestau ProteinsTHK5351amyloidcortical thicknessEarly-onset Alzheimer's diseaselate-onset Alzheimer's diseasepositron emission tomographytau

Identifiers

PMID39048319
PMCPMC11284308

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.