ArticleNature2024
Neural circuit basis of placebo pain relief.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed.
- Brain functional basis of the association between positive expectation and acupuncture efficacy in knee osteoarthritis.Brain imaging and behavior · 2026Trial
- Effect of acupuncture treatment for patients with knee osteoarthritis on brain fluctuation amplitude and functional connectivity: a randomized three-armed fMRI study.BMC complementary medicine and therapies · 2025Trial
- HSK21542 in patients with postoperative pain: two phase 3, multicentre, double-blind, randomized, controlled trials.Nature communications · 2025Trial
- Clinical Efficacy of Electroacupuncture in the Treatment of Chronic Neck Pain: A Randomized Clinical Trial.Journal of pain research · 2025Trial
- Anticipated and Actual Pain Intensity in Patients Receiving Intravitreal Injections: A Cross Sectional Study.Nursing open · 2026Article
- Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications.Experimental physiology · 2026Review
- Top-down control of the descending pain modulatory system drives multimodal placebo analgesia.Neuron · 2026Article
- Article
- Prelimbic cortex layer 5 GABAergic neurons mediate chronic pain and memory impairment by regulating excitatory/inhibitory imbalance.The journal of headache and pain · 2026Article
- Parkinson's disease: Individual placebo responses are predicted by baseline expression of a striato-limbic network.Research square · 2026Article
- Placebo analgesia persistence: evaluating behavioural stability in repeated trials.Communications biology · 2026Article
- Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice.Nature communications · 2026Article
- Brain network representations of placebo analgesia.Psychological medicine · 2026Article
- Temporal Interference Stimulation of the Motor Cortex Produces Frequency-Dependent Analgesia.bioRxiv : the preprint server for biology · 2026Article
- How does the cerebellum contribute to cognitive functions?PLoS biology · 2026Review
- Deciphering the pharmacological paradox: mechanism mismatch and stratification inadequacies in herbal-NSAID combination therapy.International journal of surgery (London, England) · 2026Article
- Placebo effect on brainstem activity associated with capsaicin-evoked urge to cough in healthy humans.The European respiratory journal · 2026Article
- Behavioral assessment of pain in rodents: advances from evoked responses to spontaneous states and multimodal approaches.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia.The Journal of clinical investigation · 2025Article
- Impaired meningeal lymphatic drainage correlates with headache intensity in episodic migraine.The journal of headache and pain · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Chong ChenDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8420-1410
Jesse K NiehausDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Fatih DincDepartment of Applied Physics, Stanford University, Stanford, CA, USA.
Karen L HuangDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexander L BarnetteDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Adrien TassouDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-2148-553X
S Andrew ShusterDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.
Lihua WangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Andrew LemireJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID 0000-0002-0624-3789
Vilas MenonDepartment of Neurology, Columbia University, New York, NY, USA.ORCID 0000-0002-4096-8601
Kimberly RitolaUNC Neuroscience Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Adam W HantmanDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0326-5878
Mark J SchnitzerDepartment of Applied Physics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-1431-8533
Grégory ScherrerDepartment of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. gregory_scherrer@med.unc.edu.ORCID 0000-0002-1983-5126
Funding
A comprehensive dissection of cell types, circuits and molecular adaptations during opioid useR01DA054583 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHERRER, GREGORY, SCHNITZER, MARK J · 2021 to 2025
$7.0MTargeting GPCRs in amygdalar and cortical neural ensembles to treat pain aversionR01NS118504 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHERRER, GREGORY · 2020 to 2024
$3.5MAmygdala mechanisms of pain aversionR01NS106301 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHERRER, GREGORY · 2018 to 2022
$1.3MCharacterizing the connectivity and molecular composition of opioid-sensitive neurons in the periaqueductal grayF32DA057779 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NIEHAUS, JESSE · 2023 to 2025
$226kNIDA NIH HHS F32 DA057779NIDA NIH HHS R01 DA054583NINDS NIH HHS R01 NS106301NINDS NIH HHS R01 NS118504
Abstract
Placebo effects are notable demonstrations of mind-body interactions
Indexed as
Neural PathwaysPainPain PerceptionPlacebo EffectAnalgesiaAnimalsAnticipation, PsychologicalCalcium SignalingCerebellumCognitionElectrophysiologyFemaleGene Expression ProfilingGyrus CinguliMaleMiceReceptors, Opioid
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Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.