Evidence map›Paper›PMID 39047965›Full record

ArticleEuropean journal of pharmacology2024

NONO2P, a novel nitric oxide donor, causes vasorelaxation through NO/sGC/PKG pathway, K

Raiana A Moraes, Daniele S Brito, Fênix A Araujo, Rafael L C Jesus, Liliane B Silva, Denise S Sá, Carlos D Silva da Silva, Laena Pernomian, Camilla F Wenceslau, Fernanda Priviero and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Antioxidants (Basel, Switzerland) · 2025
    Article
  5. Insulin resistance, CaFrontiers in physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Raiana A MoraesLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Daniele S BritoLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Fênix A AraujoLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil.
Rafael L C JesusLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil.
Liliane B SilvaLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil.
Denise S SáFederal Institute of Bahia, IFBA, Salvador, BA, Brazil.
Carlos D Silva da SilvaFederal Institute of Bahia, IFBA, Salvador, BA, Brazil.
Laena PernomianDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.
Camilla F WenceslauDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.
Fernanda PrivieroDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.
R Clinton WebbDepartment of Cell Biology and Anatomy, University of South Carolina, Columbia, SC, USA; Cardiovascular Translational Research Center, University of South Carolina, Columbia, SC, USA.
Darizy F SilvaLaboratory of Cardiovascular Physiology and Pharmacology, Bioregulation Department, Federal University of Bahia, UFBA, Salvador, Bahia, Brazil; Gonçalo Moniz Institute, FIOCRUZ, Salvador, BA, Brazil. Electronic address: darizy.silva@ufba.br.

Funding

LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunctionR01DK132948 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LAMB, FRED S, WEBB, R CLINTON · 2022 to 2025
$2.7M
Formyl peptide receptor activation induces vascular plasticity and remodeling inhypertensionR01HL149762 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2021 to 2025
$1.9M
Intrarenal Arteries Sense N-formyl Peptides Leading to Vascular Injury in SepsisR00GM118885 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WENCESLAU, CAMILLA FERREIRA · 2019 to 2021
$746k
NHLBI NIH HHS R01 HL149762NIDDK NIH HHS R01 DK132948NIGMS NIH HHS R00 GM118885
6 · The paper itself

Abstract

BACKGROUND &

aimsThe treatment of cardiovascular diseases (CVD) could greatly benefit from using nitric oxide (NO) donors. This study aimed to investigate the mechanisms of action of NONO2P that contribute to the observed responses in the mesenteric artery. The hypothesis was that NONO2P would have similar pharmacological actions to sodium nitroprusside (SNP) and NO.

methodsMale Wistar rats were euthanized to isolate the superior mesenteric artery for isometric tension recordings. NO levels were measured using the DAF-FM/DA dye, and cyclic guanosine monophosphate (cGMP) levels were determined using a cGMP-ELISA Kit.

resultsNONO2P presented a similar maximum efficacy to SNP. The free radical of NO (NO

conclusionsNONO2P induces vasorelaxation with the same magnitude as SNP, releasing NO

Indexed as

Cyclic GMPCyclic GMP-Dependent Protein KinasesNitric OxideNitric Oxide DonorsPotassium ChannelsRats, WistarSarcoplasmic Reticulum Calcium-Transporting ATPasesSignal TransductionSoluble Guanylyl CyclaseVasodilationAnimalsEnzyme ActivationGuanylate CyclaseMaleMesenteric ArteriesRatsCyclic GMPCyclic GMP-Dependent Protein KinasesGuanylate CyclaseNitric OxideNitric Oxide DonorsPotassium ChannelsSarcoplasmic Reticulum Calcium-Transporting ATPasesSoluble Guanylyl CyclaseCardiovascular effectsMesenteric arteryNO donorNONO2PNO-PathwayVasorelaxant effect

Identifiers

PMID39047965
PMCPMC11908109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.