Evidence map›Paper›PMID 39047699›Full record

ArticleNephron2024

Predicting Outcomes after Transplantation of Deceased Donor Kidneys of Marginal Quality within the Eurotransplant Service Area.

Florian G Scurt, Carl L Fischer-Fröhlich, Angela Ernst, Peter R Mertens, Jan U Becker, Christos Chatzikyrkou

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Article in Nephron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Florian G ScurtUniversity Clinic for Nephrology and Hypertension, Diabetes and Endocrinology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Carl L Fischer-FröhlichDeutsche Stiftung Organtransplantation (DSO), Stuttgart, Germany.
Angela ErnstInstitute of Medical Statistics and Bioinformatics, University of Cologne, Cologne, Germany.
Peter R MertensUniversity Clinic for Nephrology and Hypertension, Diabetes and Endocrinology, Medical Faculty, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
Jan U BeckerInstitute of Pathology, University Hospital of Cologne, Cologne, Germany.
Christos ChatzikyrkouDepartment of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKidneys of marginal quality are increasingly being used to overcome the shortage of donor organs. However, accurate prediction of outcome is needed to optimize the use of these kidneys. We aimed to test the performance of a recently proposed score consisting of delayed graft function (DGF), renal function recovery (RFR), and glomerular filtration rate (GFR) <30 mL/min per 1.73 m2 90 days after transplantation for risk assessment of patient and graft survival. MATERIAL AND

methodsA total of 221 adult brain death donors with marginal kidneys transplanted into 223 recipients within Eurotransplant were included in the analysis. Multivariable Cox proportional hazards models were constructed to assess death-censored and all-cause censored graft failure and recipient mortality at 1 and 3 years.

resultsRecipients with DGF had a higher risk of death-censored graft loss (HR, 95% CIs: 3.058 [1.195-7.825]). Recipients with a GFR <30 mL/min/1.73 m2 at 90 days after transplantation had a higher risk of death censored and all-cause graft failure (HR, 95% CIs: 2.122 [1.129-3.990] and 2.122 [1.129-3.990]). None of the three components of the proposed score was associated with a higher risk of mortality.

conclusionDGF and estimated GFR <30 mL/min/1.73 m2 but not RFR at 90 days predicted graft failure after transplantation of marginal kidneys. However, no combination of these factors was able to predict short-term patient and graft survival.

Indexed as

Delayed Graft FunctionGlomerular Filtration RateGraft SurvivalKidney TransplantationTissue DonorsAdultAgedBrain DeathEuropeFemaleHumansMaleMiddle AgedTreatment Outcome90-day outcomesDelayed graft functionGraft outcomesKidney transplantationLong-term outcomePatient outcomes

Identifiers

PMID39047699
PMCPMC11651325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.