Evidence map›Paper›PMID 39047688›Full record

ReviewPathobiology : journal of immunopathology, molecular and cellular biology2024

Reconceiving Perineural Invasion in Cutaneous Squamous Cell Carcinoma: From Biological to Histopathological Assessment.

Filippo Nozzoli, Romina Nassini, Francesco De Logu, Martina Catalano, Giandomenico Roviello, Daniela Massi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathobiology : journal of immunopathology, molecular and cellular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Filippo NozzoliSection of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.
Romina NassiniSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Francesco De LoguSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Martina CatalanoSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Giandomenico RovielloSection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, Florence, Italy.
Daniela MassiSection of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPerineural invasion (PNI) is a complex molecular process histologically represented by the presence of tumor cells within the peripheral nerve sheath and defined when infiltration into the 3 nerve sheath layers can be clearly identified. Several molecular pathways have been implicated in cSCC. PNI is a well-recognized risk factor in cutaneous squamous cell carcinoma (cSCC) and its accurate assessment represents a challenging field in pathology daily practice. SUMMARY: As a highly intricate and dynamic process, PNI involves a contingent on bidirectional signaling interactions between the tumor and various nerve components, such as Schwann cells and neurons. The current staging systems recommend the identification of PNI as a dichotomous variable (presence vs. absence) to identify a subgroup of high-risk patients. However, recent further insights revealed that the evaluation of morphological PNI-related features in cSCC may enhance the prognostic stratification of patients and may optimize the current staging guidelines for recurrence risk assessment and improvement of patient selection for postoperative adjuvant treatments. Furthermore, recent emerging biomarkers could redefine early PNI detection. KEY MESSAGES: This review provides updated insights into cSCC with PNI, focusing on molecular and cellular pathogenic processes, and aims to increase knowledge on prognostic relevant PNI-related histological features.

Indexed as

Carcinoma, Squamous CellNeoplasm InvasivenessSkin NeoplasmsBiomarkers, TumorHumansPeripheral NervesPrognosisBiomarkers, TumorCellular mechanismsCutaneous squamous cell carcinomaHistopathologyIncidental PNIPerineural invasion

Identifiers

PMID39047688
PMCPMC11614312

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.