Evidence map›Paper›PMID 39047609›Full record

ArticleEuropean journal of medicinal chemistry2024

Hydrogen peroxide responsive theranostics for cancer-selective activation of DNA alkylators and real-time fluorescence monitoring in living cells.

Eron Saxon, Taufeeque Ali, Xiaohua Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Tumor-Selective and Chemical Activation Strategies for Nitrogen Mustard Prodrugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. HJournal of medicinal chemistry · 2025
    Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eron SaxonDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer St., Milwaukee, WI, 53211, USA.
Taufeeque AliDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer St., Milwaukee, WI, 53211, USA.
Xiaohua PengDepartment of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee, 3210 N. Cramer St., Milwaukee, WI, 53211, USA. Electronic address: pengx@uwm.edu.

Funding

Novel DNA cross-linking agents and combination strategies for tumor-specific activationR15CA277656 · NCI · UNIVERSITY OF WISCONSIN MILWAUKEE · PI PENG, XIAOHUA · 2023 to 2023
$462k
NCI NIH HHS R15 CA277656
6 · The paper itself

Abstract

Triple negative breast cancer (TNBC) is a notoriously difficult disease to treat, and many of the existing TNBC chemotherapeutics lack tumor selectivity and the capability for simultaneously visualizing and monitoring their own activity in the biological context. However, TNBC cells have been known to generate high levels of reactive oxygen species (ROS), such as hydrogen peroxide (H

Indexed as

Antineoplastic AgentsFluorescent DyesHydrogen PeroxideTheranostic NanomedicineAlkylationBoron CompoundsCell Line, TumorCell ProliferationCell SurvivalCoumarinsDNADose-Response Relationship, DrugDrug Screening Assays, AntitumorFluorescenceHumansMolecular StructureAntineoplastic AgentsBoron CompoundsCoumarinsDNAFluorescent DyesHydrogen PeroxideProdrugsReactive Oxygen SpeciesAnticancer chemotherapeuticsHydrogen peroxideProdrugsProfluorophoresReactive oxygen speciesTheranostics

Identifiers

PMID39047609
PMCPMC12328069

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.