Evidence map›Paper›PMID 39047115›Full record

ArticleScience translational medicine2024

Flortaucipir PET uncovers relationships between tau and amyloid-β in primary age-related tauopathy and Alzheimer's disease.

Keith A Josephs, Nirubol Tosakulwong, Stephen D Weigand, Jonathan Graff-Radford, Christopher G Schwarz, Matthew L Senjem, Mary M Machulda, Kejal Kantarci, David S Knopman, Aivi Nguyen and 6 more

Abstract read
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Plasma eMTBR-tau243 as a disease biomarker across Alzheimer's disease clinical phenotypes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  3. Article
  4. Correlation between in vivoAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  5. Association of [Neurology · 2026
    Article
  6. Article
  7. The Role of Amyloid-β and Tau PET in the New Era of Alzheimer Disease Therapies.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Review
  8. Article
  9. Quantitation of PET spatial extent as a potential adjunct to visual interpretation of [European journal of nuclear medicine and molecular imaging · 2025
    Article
  10. Primary age-related tauopathy.Acta neuropathologica · 2025
    Review
  11. Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  12. Article
  13. Review
  14. Tau burden is best captured by magnitude and extent: Tau-MaX as a measure of global tau.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Investigating the feasibility ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Observational
  19. Article
  20. Association of in vivo retention of [Acta neuropathologica · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Keith A JosephsDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2930-8634
Nirubol TosakulwongDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2385-6835
Stephen D WeigandDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
Jonathan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-1466-8357
Matthew L SenjemDepartment of Information Technology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-9308-9275
Mary M MachuldaDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-4834-5967
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8001-2081
David S KnopmanDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6544-066X
Aivi NguyenDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1809-9451
R Ross ReichardDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0001-7189-7917
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-8178-6601
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-7916-622X
Jennifer L WhitwellDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Longitudinal multi-modality imaging in progressive apraxia of speech (Diversity Supplement)R01DC012519 · NIDCD · MAYO CLINIC ROCHESTER · PI Jennifer Louise Whitwell · 2013 to 2026
$7.2M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Understanding the role of TDP-43 in Alzheimers disease and FTLDR01AG037491 · NIA · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A · 2010 to 2024
$6.5M
Molecular and structural imaging in atypical Alzheimer's disease: a longitudinal studyR01AG050603 · NIA · MAYO CLINIC ROCHESTER · PI WHITWELL, JENNIFER LOUISE · 2016 to 2025
$5.9M
Longitudinal Multi-modal Imaging in Progressive Supranuclear Palsy SyndromesR01NS089757 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2015 to 2024
$5.6M
The neurobiology of two distinct types of progressive apraxia of speechR01DC014942 · NIDCD · MAYO CLINIC ROCHESTER · PI Keith A Josephs, Rene Lynn Utianski · 2017 to 2026
$4.9M
Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s diseaseRF1NS112153 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2021 to 2021
$1.2M
Flortaucipir PET and histopathology in frontotemporal lobar degeneration and Alzheimer’s diseaseR01NS112153 · NINDS · MAYO CLINIC ROCHESTER · PI JOSEPHS, KEITH A, WHITWELL, JENNIFER LOUISE · 2024 to 2025
$767k
NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG037491NIA NIH HHS R01 AG050603NIA NIH HHS R37 AG011378NIA NIH HHS U01 AG006786NIDCD NIH HHS R01 DC012519NIDCD NIH HHS R01 DC014942NINDS NIH HHS R01 NS089757NINDS NIH HHS R01 NS112153NINDS NIH HHS RF1 NS112153
6 · The paper itself

Abstract

[

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCarbolinesPositron-Emission TomographyTauopathiestau ProteinsAgedAged, 80 and overBrainFemaleHumansMaleMiddle Aged7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indoleAmyloid beta-PeptidesCarbolinestau Proteins

Identifiers

PMID39047115
PMCPMC11423951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.