Evidence map›Paper›PMID 39047095›Full record

ArticleScience advances2024

Dietary and water restriction leads to increased susceptibility to antimicrobial resistant pathogens.

Keenan A Lacey, Adam M Pickrum, Sandra Gonzalez, Eric Bartnicki, Ashley H Castellaw, Tori C Rodrick, Drew R Jones, Kamal M Khanna, Victor J Torres

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026
    Review
  2. Review
  3. Review
  4. The intestinal microbiota impacts nutritional immunity and resistance toProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Rehydration rescues Il22Nature communications · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Keenan A LaceyDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-9242-0170
Adam M PickrumDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-4030-6421
Sandra GonzalezDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0009-0002-0884-4200
Eric BartnickiDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0001-8959-6282
Ashley H CastellawDepartment of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0002-4149-4209
Tori C RodrickMetabolomics Core Resource Laboratory, New York University Langone Health, New York, NY 10016, USA.
Drew R JonesMetabolomics Core Resource Laboratory, New York University Langone Health, New York, NY 10016, USA.ORCID 0000-0001-8732-9818
Kamal M KhannaDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-9328-3817
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-7126-0489

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Host-pathogen interactions during hospital adaptation of MRSAR01AI137336 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, YANAI, ITAI · 2019 to 2022
$3.3M
Investigating the relationship between antibiotics and nosocomial pneumonia.R21AI149350 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TORRES, VICTOR J. · 2020 to 2021
$466k
NCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI137336NIAID NIH HHS R21 AI149350
6 · The paper itself

Abstract

Dehydration and malnutrition are common and often underdiagnosed in hospital settings. Multidrug-resistant bacterial infections result in more than 35,000 deaths a year in nosocomial patients. The effect of temporal dietary and water restriction (DWR) on susceptibility to multidrug-resistant pathogens is unknown. We report that DWR markedly increased susceptibility to systemic infection by ESKAPE pathogens. Using a murine bloodstream model of methicillin-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusPhagocytosisStaphylococcal InfectionsAnimalsDietDisease Models, AnimalDisease SusceptibilityHumansMacrophagesMiceMice, Inbred C57BLNeutrophilsWaterWater

Identifiers

PMID39047095
PMCPMC11268424

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.