Evidence map›Paper›PMID 39047044›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.

Xue Zhong, James J Moresco, Jeffrey A SoRelle, Ran Song, Yiao Jiang, Mylinh T Nguyen, Jianhui Wang, Chun Hui Bu, Eva Marie Y Moresco, Bruce Beutler and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. From Thanatos to transcription: the emerging biology of THAP proteins.Cellular and molecular life sciences : CMLS · 2026
    Review
  2. Article
  3. Article
  4. Structural insights into the ubiquitin-independent midnolin-proteasome pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xue ZhongCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
James J MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-1178-1642
Jeffrey A SoRelleDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Ran SongCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-1564-527X
Yiao JiangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Mylinh T NguyenDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Jianhui WangCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Chun Hui BuCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Eva Marie Y MorescoCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-2049-7291
Bruce BeutlerCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0002-3639-246X
Jin Huk ChoiCenter for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390.ORCID 0000-0003-2483-4379

Funding

Automated Forward Genetic Analysis of Adaptive ImmunityR01AI125581 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2016 to 2026
$19.5M
Cancer Resistant MiceR01CA258602 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI BRUCE A BEUTLER · 2022 to 2026
$3.4M
HHS | National Institutes of Health (NIH) AI125581HHS | National Institutes of Health (NIH) CA258602NCI NIH HHS R01 CA258602NIAID NIH HHS R01 AI125581
6 · The paper itself

Abstract

Despite the availability of life-extending treatments for B cell leukemias and lymphomas, many of these cancers remain incurable. Thus, the development of new molecular targets and therapeutics is needed to expand treatment options. To identify new molecular targets, we used a forward genetic screen in mice to identify genes required for development or survival of lymphocytes. Here, we describe

Indexed as

B-LymphocytesAnimalsApoptosis Regulatory ProteinsDNA-Binding ProteinsLeukemia, B-CellLymphoma, B-CellMiceMice, Inbred C57BLTranscription FactorsApoptosis Regulatory ProteinsDNA-Binding ProteinsEvi3 protein, mouseTranscription FactorsB cell malignanciescell cycleENUTHAP12ZFP574

Identifiers

PMID39047044
PMCPMC11295075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.