Evidence map›Paper›PMID 39046869›Full record

ArticleJMIR serious games2024

Immersive Virtual Reality Use in Medical Intensive Care: Mixed Methods Feasibility Study.

Brian W Locke, Te-Yi Tsai, C Mahony Reategui-Rivera, Aileen S Gabriel, Aref Smiley, Joseph Finkelstein

2 registry-linked trialsAbstract read
In one paragraph

Article in JMIR serious games, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07585500 narecruitingnot on this mapstarted 2025, after this paper: background citation

Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Protocol for a Pilot Randomized Controlled Trial for Cognitive, Physical and Psychological Outcomes

TypeinterventionalSponsorUniversity of MinhoRan2025 to 2026Enrolled51ConditionsPost-Intensive Care Syndrome (PICS), Critical Illness Recovery, Rehabilitation After Critical Illness, Rehabilitation Exercise of ICU PatientsArmsImmersive VR Multi-Domain Rehabilitation, Tablet-Based Multi-Domain Training
NCT07649876 narecruitingnot on this mapstarted 2026, after this paper: background citation

Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2026 to 2026Enrolled30ConditionsDelirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety AcuteArmsVirtual reality (VR) therapy
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Addressing challenges for virtual reality applications in the ICU.Journal of anesthesia, analgesia and critical care · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brian W LockeDivision of Respiratory, Critical Care, and Occupational Pulmonary Medicine, Department of Internal Medicine, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-3588-5238
Te-Yi TsaiDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-9118-3978
C Mahony Reategui-RiveraDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-4030-8777
Aileen S GabrielDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-5872-9078
Aref SmileyDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-1077-2229
Joseph FinkelsteinDepartment of Biomedical Informatics, University of Utah, Salt Lake City, UT, United States.ORCID https://orcid.org/0000-0002-8084-7441

Funding

CTSA UM1 Program at University of UtahUM1TR004409 · NCATS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RACHEL HESS, Jennifer Juhl Majersik · 2023 to 2026
$21.9M
Multidisciplinary Pulmonary and Critical Care Training ProgramT32HL105321 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Ramsey Hachem, Robert Paine · 2010 to 2026
$4.5M
Comprehensive Health Informatics Engagement Framework for Pulmonary RehabR33HL143317 · NHLBI · UNIVERSITY OF UTAH · PI FINKELSTEIN, JOSEPH E, STEIN, JOEL · 2020 to 2022
$2.4M
NCATS NIH HHS UM1 TR004409NHLBI NIH HHS R33 HL143317NHLBI NIH HHS T32 HL105321
6 · The paper itself

Abstract

backgroundImmersive virtual reality (VR) is a promising therapy to improve the experience of patients with critical illness and may help avoid postdischarge functional impairments. However, the determinants of interest and usability may vary locally and reports of uptake in the literature are variable.

objectiveThe aim of this mixed methods feasibility study was to assess the acceptability and potential utility of immersive VR in critically ill patients at a single institution.

methodsAdults without delirium who were admitted to 1 of 2 intensive care units were offered the opportunity to participate in 5-15 minutes of immersive VR delivered by a VR headset. Patient vital signs, heart rate variability, mood, and pain were assessed before and after the VR experience. Pre-post comparisons were performed using paired 2-sided t tests. A semistructured interview was administered after the VR experience. Patient descriptions of the experience, issues, and potential uses were summarized with thematic analysis.

resultsOf the 35 patients offered the chance to participate, 20 (57%) agreed to partake in the immersive VR experience, with no difference in participation rate by age. Improvements were observed in overall mood (mean difference 1.8 points, 95% CI 0.6-3.0; P=.002), anxiety (difference of 1.7 points, 95% CI 0.8-2.7; P=.001), and pain (difference of 1.3 points, 95% CI 0.5-2.1; P=.003) assessed on 1-10 scales. The heart rate changed by a mean of -1.1 (95% CI -0.3 to -1.9; P=.008) beats per minute (bpm) from a baseline of 86.1 (SD 11.8) bpm and heart rate variability, assessed by the stress index (SI), changed by a mean of -5.0 (95% CI -1.5 to -8.5; P=.004) seconds

conclusionsPatient acceptance of immersive VR was high in a mostly medical intensive care population with little prior VR experience. Patients commented on the potential of immersive VR to ameliorate cognitive and emotional symptoms. Investigators can consider integrating minimally modified commercial VR headsets into the existing intensive care unit workflow to further assess VR's efficacy for a variety of endpoints.

Indexed as

adultcritical illnesscritically illdistraction therapyfeasibility studygames for healthgamificationimmersive virtual realityintensive care unitmixed methodspatient acceptancesemistructured interviewserious gamestherapisttherapyuser experiencevirtual reality

Identifiers

PMID39046869
PMCPMC11344185

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.