Evidence map›Paper›PMID 39046627›Full record

ArticleObesity surgery2024

Autonomic and Enteric Profiling May Help Predict Response to Diverse Obesity Therapies.

Michael Eiswerth, Prateek Mathur, Hani Rashed, Frank Greenway, Eric Ravussin, William Johnson, Pichamol Jirapinyo, Christopher C Thompson, Farid Kehdy, Shabnam Sarker and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Michael EiswerthDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA.
Prateek MathurDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA.
Hani RashedVanderbilt University Medical Center, Nashville, TN, 37235, USA.
Frank GreenwayPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Eric RavussinVanderbilt University Medical Center, Nashville, TN, 37235, USA.
William JohnsonVanderbilt University Medical Center, Nashville, TN, 37235, USA.
Pichamol JirapinyoBrigham and Women's Hospital, Boston, MA, 02115, USA.
Christopher C ThompsonBrigham and Women's Hospital, Boston, MA, 02115, USA.
Farid KehdyDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA.
Shabnam SarkerVanderbilt University Medical Center, Nashville, TN, 37235, USA.
Le Yu NaingDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA.
Michael W DanielsDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA.
Thomas AbellDivision of Gastroenterology, Hepatology, and Nutrition, GI Motility Research, University of Louisville, 8 Frazier, 220 Abraham Flexner Dr, Louisville, KY, 40202, USA. thomas.abell@louisville.edu.ORCID 0000-0002-3175-5161

Funding

Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI ROBERT A KESTERSON · 2005 to 2026
$26.5M
NIDDK NIH HHS P30 DK072476
6 · The paper itself

Abstract

purposeChanges in autonomic (ANS) and enteric nervous systems (ENS) may be involved in pathogenesis of obesity. We hypothesized that baseline autonomic and enteric parameters may predict outcomes of diverse obesity therapies. MATERIAL AND

methodsWe studied ANS and ENS physiology in 37 patients (8 male, 29 female, age 45 years, weight 129.7 kg) at 4 centers in patients undergoing medical (9: low-calorie diet) versus invasive (22: 16 sleeve, 6 bypass) and semi-invasive (6: 2 band, 2 high energy stimulation, 2 aspiration) weight loss therapies. Weight loss was reported as percent weight loss from baseline to latest values at 1 year and in some up to 5 years; classified as < or > /= 20% for each group. ANS testing included sympathetic adrenergic function by measuring reflex vasoconstriction and postural adjustment ratio. ENS was measured non-invasively using cutaneous low-resolution electrogastrogram.

resultsPercent weight loss was greater with the invasive (28.5%) than semi-invasive (9.1%) or non-invasive low-calorie diet (4.4%) (p < .001). Percent weight loss at 1 year (and up to 5 years) corresponded to the adrenergic measure of postural adjustment ratio (r = .42, p = .012), total pulse amplitude at rest (r = .56, p < .001), and electrogastrogram standing-to-rest difference (r = .33, p = .056).

conclusionBaseline autonomic and enteric function measures correspond to percentage with loss in this pilot study using diverse weight loss methods. Autonomic and enteric profiling has potential clinical use for evaluation and treatment of obesity but needed larger controlled trials.

Indexed as

Autonomic Nervous SystemObesity, MorbidWeight LossAdultBariatric SurgeryCaloric RestrictionDiet, ReducingEnteric Nervous SystemFemaleHumansMaleMiddle AgedObesityPredictive Value of TestsTreatment OutcomeAutonomic Nervous SystemEnteric Nervous SystemObesityWeight Loss

Identifiers

PMID39046627
PMCPMC12033003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.