ArticleMetabolomics : Official journal of the Metabolomic Society2024
A study of 9 common breath VOCs in 504 healthy subjects using PTR-TOF-MS.
Article in Metabolomics : Official journal of the Metabolomic Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Correlation Between Breath Acetone and Ketone Bodies in Blood and Urine Among Individuals with Different Glycometabolic Statuses Based on PTR-TOF-MS.Diagnostics (Basel, Switzerland) · 2026Article
- Soft ionization by chemical reaction in transfer-high-resolution mass spectrometry for clinical exhaled breath profiling.Analytical and bioanalytical chemistry · 2026Article
- Harnessing breath biomarkers for pneumonia diagnosis and prognosis.Expert review of respiratory medicine · 2026Review
- Intermittent Hypoxia-Induced Inflammation and the Formation of Exhaled Volatile Organic Compound Profiles in Obstructive Sleep Apnea-Hypopnea Syndrome: A Narrative Review.Nature and science of sleep · 2026Review
- Uronium from X-ray-Desorbed Urea Enables Sustainable Ultrasensitive Detection of Amines and Semivolatiles.Analytical chemistry · 2025Article
- Non-Invasive Detection of Nasopharyngeal Carcinoma Using Volatile Organic Compounds.Metabolites · 2025Article
- Multivariate evaluation method for the detection of pest infestations on plants via VOC analysis using gas chromatography mass spectrometry.Scientific reports · 2025Article
- High Concordance of E-Nose-Derived Breathprints in a Healthy Population: A Cross-Sectional Observational Study.Sensors (Basel, Switzerland) · 2025Observational
- Breath Analysis via Surface Enhanced Raman Spectroscopy.ACS sensors · 2025Review
- Article
- Rapid Identification of Carbapenem-ResistantInfection and drug resistance · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThis study employs Proton-Transfer-Reaction Mass Spectrometry (PTR-MS) to analyze exhaled breath profiles of 504 healthy adults, focusing on nine common volatile organic compounds (VOCs): acetone, acetaldehyde, acetonitrile, ethanol, isoprene, methanol, propanol, phenol, and toluene. PTR-MS offers real-time VOC measurement, crucial for understanding breath biomarkers and their applications in health assessment.
objectivesThe study aims to investigate how demographic factors-gender, age, and smoking history-affect VOC concentrations in exhaled breath. The objective is to enhance our understanding of breath biomarkers and their potential for health monitoring and clinical diagnosis.
methodsExhaled breath samples were collected using PTR-MS, measuring concentrations of nine VOCs. The data were analyzed to discern distribution patterns across demographic groups.
resultsMales showed higher average VOC levels for certain compounds. Propanol and methanol concentrations significantly increased with age. Smoking history influenced VOC levels, with differences among non-smokers, current smokers, and ex-smokers.
conclusionThis research provides valuable insights into demographic influences on exhaled VOC profiles, emphasizing the potential of breath analysis for health assessment. PTR-MS's real-time measurement capabilities are crucial for capturing dynamic VOC changes, offering advantages over conventional methods. These findings lay a foundation for advancements in non-invasive disease detection, highlighting the importance of considering demographics in breath biomarker research.
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