The association between endoplasmic reticulum aminopeptidase 2 gene single nucleotide polymorphisms and the risk of psoriasis and psoriatic arthritis in Egyptians.

Mona A Abbas, Maha A A Masry, Salah M ALQusi, Mahmoud M Hadhoud, Eman A M Fouda

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Mona A AbbasDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Menoufia University, Yassen Abd Al Ghafar Street, Shebin El-Kom City, Menoufia governorate, 32511, Egypt. mona.abbass@med.menofia.edu.eg.ORCID http://orcid.org/0000-0001-5591-4414

Maha A A Masry *Faculty of Science, Al-Azhar University, Cairo, Egypt.

Salah M ALQusiDepartment of Organic Chemistry, Faculty of Science, Menoufia University, Menoufia, Egypt.

Mahmoud M HadhoudDepartment of Orthopedic Surgery, Faculty of Medicine, Menoufia University, Menoufia, Egypt.

Eman A M FoudaDepartment of Biochemistry, Faculty of Science, Menoufia University, Menoufia, Egypt.

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6 · The paper itself

Abstract

backgroundPsoriasis (Ps) is a disorder attributed to the immune system that involves inflammation of the skin and joints. Psoriasis is a multifactorial disorder in which genetic factors represent about 70% of the disease risk. This study aims to establish the correlation between the ERAP2 gene's single nucleotide polymorphisms (SNPs) rs2910686 and rs2248374 with the susceptibility to Ps and/or psoriatic arthritis (PsA) among the Egyptian population. METHODS AND

resultsGenotyping of ERAP2 gene SNPs (rs2910686 and rs2248374) in 120 psoriatic patients with and without arthritis and 100 controls was done using real-time PCR. The genotype frequency and distribution of the ERAP2 SNP (rs2910686 and rs2248374) were in Hardy-Weinberg equilibrium (HWE). For rs2910686, the TC and CC genotypes and C allele frequency were significant risk factors for PsA compared to the controls (OR = 5.708, OR = 10.165, and OR = 4.282, respectively). They also were significant risk factors for Ps compared to the controls (OR = 5.165, OR = 5.040, and OR = 3.258, respectively). For rs2248374, the AG genotype significantly increased the risk of PsA (OR = 2.605) and Ps (OR = 3.768) compared to controls. The AG genotype was significantly related to the risk of Ps (OR = 3.369) G allele with PsA (OR = 1.608) and Ps (OR = 1.965) compared to controls.

conclusionIn Egyptian individuals, the ERAP2 gene polymorphisms (rs2248374 and rs2910686) may contribute genetically to the pathophysiology of psoriasis and PsA.

Indexed as

AminopeptidasesArthritis, PsoriaticGene FrequencyGenetic Predisposition to DiseasePolymorphism, Single NucleotidePsoriasisAdultAllelesCase-Control StudiesEgyptFemaleGenetic Association StudiesGenotypeHumansMaleMiddle AgedAminopeptidasesERAP2 protein, humanERAP2PolymorphismPsoriasisPsoriatic arthritisReal-time PCR

Identifiers

PMID39046539

DOI10.1007/s11033-024-09733-w

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