Evidence map›Paper›PMID 39046472›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2025

Impact of heart failure severity on the mortality benefit of mitral transcatheter edge-to-edge valve repair.

Valeria Magni, Marianna Adamo, Elisa Pezzola, Antonio Popolo Rubbio, Cristina Giannini, Giulia Masiero, Carmelo Grasso, Paolo Denti, Arturo Giordano, Federico De Marco and 22 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Valeria MagniDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Marianna AdamoDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. mariannaadamo@hotmail.com.ORCID http://orcid.org/0000-0002-3855-1815
Elisa PezzolaDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Antonio Popolo RubbioDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Cristina GianniniCardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Giulia MasieroInterventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua, Italy.
Carmelo GrassoDivision of Cardiology, Centro Alte Specialità e Trapianti (CAST), Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.
Paolo DentiCardiac Surgery Department, San Raffaele University Hospital, Milan, Italy.
Arturo GiordanoInvasive Cardiology Unit, Pineta Grande Hospital, Castel Volturno, Caserta, Italy.
Federico De MarcoCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Antonio L BartorelliCentro Cardiologico Monzino, IRCCS, Milan, Italy.
Matteo MontorfanoInterventional Cardiology Unit IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cosmo GodinoInterventional Cardiology Unit IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cesare BaldiHospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
Francesco De FeliceDivision of Interventional Cardiology, Azienda Ospedaliera S. Camillo Forlanini, Rome, Italy.
Annalisa MongiardoDivision of Cardiology, University Magna Graecia, Catanzaro, Italy.
Ida MonteforteAORN Ospedali dei Colli, Monaldi Hospital, Naples, Italy.
Emmanuel VillaCardiac Surgery Unit Poliambulanza Hospital, Fondazione Poliambulanza, Brescia, Italy.
Gabriele CrimiCardiac Catheterization Laboratory, Policlinico San Martino, Genoa, Italy.
Maurizio TusaDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Luca TestaDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Lisa SerafiniDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Dario CaniDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Giacinta GuariniDivision of Cardiology, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Alda HuqiDivision of Cardiology, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Marco SesanaDivision of Cardiology, Ospedale di Desenzano, Desenzano, Italy.
Marco De CarloCardiac Catheterization Laboratory, Cardiothoracic and Vascular Department, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
Francesco MaisanoCardiac Surgery Department, San Raffaele University Hospital, Milan, Italy.
Giuseppe TarantiniInterventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Science, University of Padua, Padua, Italy.
Corrado TamburinoDivision of Cardiology, Centro Alte Specialità e Trapianti (CAST), Azienda Ospedaliero-Universitaria Policlinico-Vittorio Emanuele, University of Catania, Catania, Italy.
Francesco BedogniDepartment of Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
Marco MetraDivision of Cardiology and Cardiac Catheterization Laboratory, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the interaction between heart failure (HF) severity and optimal reduction of secondary mitral regurgitation (SMR) on mortality in patients undergoing transcatheter edge-to-edge repair (M-TEER). METHODS AND

resultsAmong 1656 patients included in the Italian Society of Interventional Cardiology (GIse) registry Of Transcatheter treatment of mitral valve regurgitaTiOn (GIOTTO) 984 had SMR and complete data on advanced HF. Advanced HF was defined as NYHA class III or IV, left ventricular ejection fraction ≤ 30%, and > 1 HF hospitalization during the last 12 months. Optimal M-TEER was defined as residual SMR ≤ 1 + at discharge. One hundred sixteen patients (11.8%) had advanced HF. Achievement of an optimal SMR reduction was similar in patients with and without advanced HF (65% and 60% respectively). Advanced HF was an independent predictor of 2-year all-cause death (adjusted HR 1.52, 95% CI 1.09-2.10). Optimal M-TEER, as compared to a no-optimal M-TEER, was associated with a reduced risk of death both in patients with advanced (HR 0.55, 95% CI 0.32-0.97; p = 0.039) and no-advanced HF (HR 0.59, 95% CI 0.46-0.78; p < 0.001; p = 0.778 for interaction).

conclusionsAdvanced HF is associated with poor outcome in patients undergoing M-TEER. However, an optimal SMR reduction reduces the risk of 2-year mortality regardless of HF severity.

Indexed as

Cardiac CatheterizationHeart FailureHeart Valve Prosthesis ImplantationMitral ValveMitral Valve InsufficiencyAgedAged, 80 and overCause of DeathFemaleFollow-Up StudiesHumansItalyMaleRegistriesRisk FactorsSeverity of Illness IndexAdvanced heart failureMitral transcatheter edge-to-edge repairSecondary mitral regurgitation

Identifiers

PMID39046472
PMCPMC12202617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.