ArticleAnnals of the rheumatic diseases1985
IgE deposition in normal skin of patients with rheumatoid arthritis in relation to clinical and laboratory findings.
Article in Annals of the rheumatic diseases, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- B-cell involvement in the pathogenesis of RA-is there a contribution of the sympathetic nervous system?Immunologic research · 2008Review
- B lymphocytes and humoral immune responses in rheumatoid arthritis.Clinical rheumatology · 1995Review
- Experimental arthritis in rats induced by intra-articular injection of IgE aggregates: evidence for arthritogenic role of complexed IgE.Annals of the rheumatic diseases · 1992Article
- Activation of inflammatory cells by immune complexes containing IgE in serum and synovial fluid of patients with rheumatoid arthritis: a study using flow cytometric analysis.Annals of the rheumatic diseases · 1991Article
- Cholesterol crystals and IgE-containing immune complexes in rheumatoid pericarditis.Clinical rheumatology · 1991Article
- IgE-containing immune complexes in synovial fluid of patients with rheumatoid arthritis.Clinical rheumatology · 1990Article
- Clinical significance of anti-IgE autoantibodies and immune complexes containing IgE.Clinical reviews in allergy · 1989Review
- Role of IgM-rheumatoid factor interference in the determination of total serum IgE and IgE-containing circulating immune complexes.Clinical and experimental immunology · 1988Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biopsy specimens from apparently normal skin of 28 patients with classical or definite rheumatoid arthritis (RA) were examined for the presence of IgE deposition by a direct immunofluorescence technique. IgE deposition was found in 12 patients (43%) and in none of the 10 controls. This deposition was mainly localised on mast cells, and in three patients perivascular IgE staining was also noted. The skin from nine of the 12 patients also showed deposition of IgM and complement C3 or C4 factor, or both. All 12 patients with skin IgE deposition had raised levels of IgM rheumatoid factor (RF) in the serum. Nine of these also had IgE RF. IgE-containing circulating immune complexes (IgE CIC), raised serum IgE levels, and extra-articular (EA) manifestations were present in respectively 10, nine, and eight skin IgE positive patients. It is suggested that IgE and IgE CIC may be involved in the pathogenesis of RA and its EA manifestations.
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