Evidence map›Paper›PMID 39046261›Full record

ArticleMicrobiology spectrum2024

Characterization of natural product inhibitors of quorum sensing reveals competitive inhibition of

Kathryn E Woods, Sana Akhter, Blanca Rodriguez, Kade A Townsend, Nathan Smith, Ben Smith, Alice Wambua, Vaughn Craddock, Rhea G Abisado-Duque, Emma E Santa and 6 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Anti-QS Strategies AgainstMicroorganisms · 2025
    Review
  10. Article
  11. Quorum Sensing and its Inhibition inCurrent drug targets · 2025
    Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kathryn E WoodsDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0009-0008-5376-6989
Sana AkhterCenter for Computational Biology, University of Kansas, Lawrence, Kansas, USA.
Blanca RodriguezDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0009-0005-9428-8176
Kade A TownsendDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Nathan SmithDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Ben SmithDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Alice WambuaDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Vaughn CraddockDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Rhea G Abisado-DuqueDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Emma E SantaDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel E MansonDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Berl R OakleyDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Lynn E HancockDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0003-3372-5406
Yinglong MiaoDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.
Helen E BlackwellDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-4261-8194
Josephine R ChandlerDepartment of Molecular Biosciences, University of Kansas, Lawrence, Kansas, USA.ORCID 0000-0001-8944-9813

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Chemical Strategies to Modulate Intercellular Bacterial CommunicationR35GM131817 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Helen E. Blackwell · 2019 to 2026
$2.9M
Quorum sensing evolution and function in mixed bacterial communitiesR35GM133572 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI CHANDLER, JOSEPHINE R · 2019 to 2024
$2.1M
MARC at The University of KansasT34GM136453 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Paulyn Cartwright, Stuart John Macdonald · 2020 to 2026
$1.9M
Fulbright U.S. Student Program 15160174HHS | National Institutes of Health (NIH) T34GM136453NIGMS NIH HHS P20 GM103418NIGMS NIH HHS R35 GM131817NIGMS NIH HHS R35 GM133572NIGMS NIH HHS T34 GM136453NIH HHS R35GM133572
6 · The paper itself

Abstract

Quorum sensing (QS) is a cell-cell signaling system that enables bacteria to coordinate population density-dependent changes in behavior. This chemical communication pathway is mediated by diffusible IMPORTANCE: Quorum sensing (QS) regulates many aspects of bacterial pathogenesis and has attracted much interest as a target for anti-virulence therapies over the past 30 years, for example, antagonists of the LasR and RhlR QS receptors in

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBenzaldehydesBiological ProductsPseudomonas aeruginosaQuorum SensingTrans-ActivatorsAnti-Bacterial AgentsBacterial ProteinsBenzaldehydesBiological ProductsLasR protein, Pseudomonas aeruginosaRhlR protein, Pseudomonas aeruginosaTrans-Activatorsvanillinanti-virulenceinhibitorLasRPseudomonas aeruginosaquorum sensingRhlRvanillin

Identifiers

PMID39046261
PMCPMC11370260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.