Evidence map›Paper›PMID 39046031›Full record

ArticleHuman brain mapping2024

Large-scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents.

F Kurth, D Schijven, O A van den Heuvel, M Hoogman, D van Rooij, D J Stein, J K Buitelaar, S Bölte, G Auzias, A Kushki and 76 more

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Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Autism and Cortical Thickness Deviation From Neurotypical Controls: Evidence for a Spatial Association With Serotonin Receptors.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

86 authors.

F KurthSchool of Psychology, University of Auckland, Auckland, New Zealand.ORCID 0000-0001-8662-1809
D SchijvenLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
O A van den HeuvelDepartment of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
M HoogmanDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-1261-7628
D van RooijDonders Institute for Brain, Cognition and Behavior, Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
D J SteinSAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
J K BuitelaarDonders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
S BölteCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
G AuziasInstitut de neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France.
A KushkiHolland Bloorview Kids Rehabilitation Hospital, Institute for Biomedical Engineering, University of Toronto, Toronto, Canada.
G VenkatasubramanianNational Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
K RubiaInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID 0000-0002-1410-7701
S BollmannSchool of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia.
J IsakssonCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
F Jaspers-FayerBC Children's Research Institute and the University of British Columbia, Vancouver, Canada.
R MarshDepartment of Psychiatry, Columbia University Irving Medical Center and the New York State Psychiatric Institute, New York, New York, USA.
M C BatistuzzoDepartment & Institute of Psychiatry, University of Sao Paulo, Medical School, Sao Paulo, Brazil.
P D ArnoldThe Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
R A BressanFederal University of São Paulo, São Paulo, Brazil.
S E StewartBritish Columbia Children's Hospital, British Columbia Mental Health and Substance Use Services, University of British Columbia, Vancouver, Canada.
P GrunerDepartment of Psychiatry, Yale University, New Haven, Connecticut, USA.
L SorensenDepartment of Biological and Medical Psychology, University of Bergen, Bergen, Norway.
P M PanLaboratório de Neurociências Integrativas (LINC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
T J SilkCentre for Social and Early Emotional Development and School of Psychology, Deakin University, Geelong, Australia.
R C GurDepartment of Psychiatry, Section on Neurodevelopment and Psychosis and the Lifespan Brain Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
A I CubilloInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
J HaavikDepartment of Biomedicine, University of Bergen, Bergen, Norway.
R L O'Gorman TuuraCenter for MR Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
C A HartmanInterdisciplinary Center Psychopathology and Emotion Regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
R CalvoDepartment of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
J McGrathDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
S CalderoniIRCCS Stella Maris Foundation, Pisa, Italy.
A JackowskiDepartment of Psychiatry, UNIFESP, São Paulo, Brazil.
K C ChantilukeInstitute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
T D SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
G F BusattoDepartment of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
J T NiggDepartment of Psychiatry and Center for ADHD Research, Oregon Health & Science University, Portland, Oregon, USA.
R E GurDepartment of Psychiatry, The Penn-CHOP Lifespan Brain Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
A ReticoPisa Division, National Institute for Nuclear Physics (INFN), Pisa, Italy.ORCID 0000-0001-5135-4472
M TosettiIRCCS Stella Maris Foundation, Pisa, Italy.
L GallagherDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
P R SzeszkoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
J NeufeldCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
A E OrtizDepartment of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
C GhisleniCenter for MR Research, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
L LazaroDepartment of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
P J HoekstraDepartment of Child and Adolescent Psychiatry & Accare Child Study Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
E AnagnostouHolland Bloorview Kids Rehabilitation Hospital, Department of Pediatrics, Temetry School of Medicine, University of Toronto, Toronto, Canada.
L HoekstraKarakter University Center for Child and Adolescent Psychiatry, Nijmegen, The Netherlands.
B SimpsonNew York State Psychiatric Institute/CUIMC, New York, New York, USA.
J K PlessenDivision of Child and Adolescent Psychiatry, Department of Psychiatry, University Hospital Lausanne, Lausanne, Switzerland.
C DeruelleInstitut de neurosciences de la Timone UMR 7289, Aix-Marseille Université & CNRS, Marseille, France.
N SoreniPediatric OCD Consultation Clinic, SJH, Hamilton, Canada.
A JamesDepartment of Psychiatry, University of Oxford, Oxford, UK.
J NarayanaswamyNational Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
J Y ReddyNational Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
J FitzgeraldTrinity College Dublin, Dublin, Ireland.ORCID 0000-0001-6553-4378
M A BellgroveSchool of Psychological Sciences and Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia.
G A SalumGraduate Program of Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
J JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
F MuratoriIRCCS Stella Maris Foundation, Pisa, Italy.
M VilaDepartment of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
M Garcia GiralDepartment of Child and Adolescent Psychiatry and Psychology, Neuroscience Institute, Hospital Clinic, Barcelona, Spain.
S H AmeisCampbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada.
P BoscoIRCCS Stella Maris Foundation, Pisa, Italy.
K Lundin RemnéliusCenter of Neurodevelopmental Disorders (KIND), Centre for Psychiatry Research, Department of Women's and Children's Health, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Stockholm, Sweden.
C HuyserAcademic Center Child and Youth Psychiatry, Levvel, Amsterdam, The Netherlands.
J C ParienteMagnetic Resonance Image Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
M JalbrzikowskiDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
P G RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
K M O'HearnAtrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.
S EhrlichDivision of Psychological and Social Medicine and Developmental Neurosciences & Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany.
J MollonBoston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
A ZugmanNational Institutes of Health/National Institute of Mental Health, Bethesda, Maryland, USA.ORCID 0000-0002-6126-7759
A ChristakouInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
C ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, School of Medicine, Universidad Complutense, CIBERSAM, Madrid, Spain.
S E FisherLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
X KongDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
B FrankeDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
S E MedlandQIMR Berghofer Medical Research Institute, Herston, Australia.ORCID 0000-0003-1382-380X
S I ThomopoulosImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.ORCID 0000-0002-0046-4070
N JahanshadImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
D C GlahnDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
P M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, California, USA.
C FrancksLanguage and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.ORCID 0000-0002-9098-890X
E LudersSchool of Psychology, University of Auckland, Auckland, New Zealand.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1M
ADHD heterogeneity, mechanisms, and risk profileR37MH059105 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI NIGG, JOEL T · 2014 to 2023
$7.0M
Longitudinal Mapping of Network Development Underlying Executive Dysfunction in AdolescenceR01MH113550 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Danielle Smith Bassett, Theodore Satterthwaite · 2018 to 2026
$6.9M
Inter-modal Coupling Image AnalyticsR01MH112847 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Theodore Satterthwaite, Russell Takeshi Shinohara · 2017 to 2026
$5.9M
In Vivo Hematopoietic Stem Cell Gene Therapy of Beta-Thalassemia and Sickle Cell DiseaseR01HL130040 · NHLBI · UNIVERSITY OF WASHINGTON · PI LIEBER, ANDRE MICHAEL · 2016 to 2024
$4.3M
Evolution of Psychosis in Youth: Multimodal Risk and Resilience MarkersR01MH119219 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E, GUR, RUBEN C. · 2019 to 2023
$3.8M
Reproducible imaging-based brain growth charts for psychiatryR01MH120482 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI MILHAM, MICHAEL PETER, SATTERTHWAITE, THEODORE · 2019 to 2023
$3.5M
ENIGMA World Aging CenterR01AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2021 to 2025
$3.3M
Control and Reward Circuits as Targets for Repetitive Thoughts and BehaviorsR01MH104648 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MARSH, RACHEL, SIMPSON, HELEN BLAIR · 2014 to 2017
$2.8M
Network Control and Functional Context: Mechanisms for TMS ResponseRF1MH116920 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, OATHES, DESMOND · 2018 to 2018
$2.8M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
A global alliance to unlock brain mechanisms influencing suicidal behaviors through the ENIGMA ConsortiumR01MH117601 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA, SCHMAAL, LIANNE · 2018 to 2021
$1.5M
Medical Research CouncilNHLBI NIH HHS R01 HL130040NIA NIH HHS R01 AG058854NIBIB NIH HHS P41 EB015922NIMH NIH HHS K23 MH115206NIMH NIH HHS R01 MH104648NIMH NIH HHS R01 MH112847NIMH NIH HHS R01 MH113550NIMH NIH HHS R01 MH114879NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R01 MH119219NIMH NIH HHS R01 MH120482NIMH NIH HHS R21 MH101441NIMH NIH HHS R37 MH059105NIMH NIH HHS RF1 MH116920
6 · The paper itself

Abstract

Only a small number of studies have assessed structural differences between the two hemispheres during childhood and adolescence. However, the existing findings lack consistency or are restricted to a particular brain region, a specific brain feature, or a relatively narrow age range. Here, we investigated associations between brain asymmetry and age as well as sex in one of the largest pediatric samples to date (n = 4265), aged 1-18 years, scanned at 69 sites participating in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our study revealed that significant brain asymmetries already exist in childhood, but their magnitude and direction depend on the brain region examined and the morphometric measurement used (cortical volume or thickness, regional surface area, or subcortical volume). With respect to effects of age, some asymmetries became weaker over time while others became stronger; sometimes they even reversed direction. With respect to sex differences, the total number of regions exhibiting significant asymmetries was larger in females than in males, while the total number of measurements indicating significant asymmetries was larger in males (as we obtained more than one measurement per cortical region). The magnitude of the significant asymmetries was also greater in males. However, effect sizes for both age effects and sex differences were small. Taken together, these findings suggest that cerebral asymmetries are an inherent organizational pattern of the brain that manifests early in life. Overall, brain asymmetry appears to be relatively stable throughout childhood and adolescence, with some differential effects in males and females.

Indexed as

BrainMagnetic Resonance ImagingSex CharacteristicsAdolescentAdolescent DevelopmentAge FactorsChildChild DevelopmentChild, PreschoolFemaleFunctional LateralityHumansInfantMaleadolescenceageasymmetrybrainchildhoodcortical thicknessdevelopmentENIGMAgendergray mattersex

Identifiers

PMID39046031
PMCPMC11267452

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.