Evidence map›Paper›PMID 39045854›Full record

Observational studyHealth technology assessment (Winchester, England)2024

Treatment options for patients with pilonidal sinus disease: PITSTOP, a mixed-methods evaluation.

Steven Brown, Daniel Hind, Emily Strong, Mike Bradburn, Farhat Vanessa Nasim Din, Ellen Lee, Matthew J Lee, Jonathan Lund, Christine Moffatt, Jonathan Morton and 8 more

Abstract readObservational Study
In one paragraph

Observational study in Health technology assessment (Winchester, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Steven BrownDepartment of General Surgery, Northern General Hospital, Sheffield, UK.ORCID 0000-0002-0980-2793
Daniel HindSheffield Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0002-6409-4793
Emily StrongSheffield Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0002-2381-4088
Mike BradburnSheffield Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0002-3783-9761
Farhat Vanessa Nasim DinAcademic Coloproctology, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.ORCID 0000-0001-5466-8282
Ellen LeeSheffield Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0003-4529-7410
Matthew J LeeDepartment of Oncology and Metabolism, The Medical School, University of Sheffield, Sheffield, UK.ORCID 0000-0001-9971-1635
Jonathan LundDerby Royal Infirmary, University Hospitals of Derby and Burton, Derby, UK.ORCID 0000-0001-5195-2181
Christine MoffattNottingham University Hospitals NHS Trust, Nottingham, UK.ORCID 0000-0002-2436-0129
Jonathan MortonAddenbrookes Hospital, Cambridge University Hospitals, Cambridge, UK.ORCID 0000-0003-0544-5474
Asha SenapatiSt Mark's Hospital, London, UK; Queen Alexandra Hospital, Portsmouth, UK.ORCID 0000-0003-2597-9967
Philip ShackleySchool of Health and Related Research, Regent Court, Sheffield, UK.ORCID 0000-0002-1862-0596
Peter Vaughan-ShawDepartment of Colorectal Surgery, Western General Hospital, Edinburgh, UK.ORCID 0000-0002-9790-6882
Arkadiusz Peter WysockiGriffiths University Medical School, Brisbane, Australia.ORCID 0000-0001-6880-9285
Tia CallaghanSheffield Clinical Trials Research Unit, School of Health and Related Research (ScHARR), University of Sheffield, Sheffield, UK.ORCID 0000-0003-3255-2849
Helen JonesOxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0001-8238-7779
Nyantara WickramasekeraSchool of Health and Related Research, Regent Court, Sheffield, UK.ORCID 0000-0002-6552-5153
PITSTOP Management Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: There is no consensus on optimal management of pilonidal disease. Surgical practice is varied, and existing literature is mainly single-centre cohort studies of varied disease severity, interventions and outcome assessments. Objectives: A prospective cohort study to determine: • disease severity and intervention relationship • most valued outcomes and treatment preference by patients • recommendations for policy and future research. Design: Observational cohort study with nested mixed-methods case study. Discrete choice experiment. Clinician survey. Three-stage Delphi survey for patients and clinicians. Inter-rater reliability of classification system. Setting: Thirty-one National Health Service trusts. Participants: Patients aged > 16 years referred for elective surgical treatment of pilonidal disease. Interventions: Surgery. Main outcome measures: Pain postoperative days 1 and 7, time to healing and return to normal activities, complications, recurrence. Outcomes compared between major and minor procedures using regression modelling, propensity score-based approaches and augmented inverse probability weighting to account for measured potential confounding features. Results: Limitations: Incomplete recruitment and follow-up data were an issue, particularly given the multiple interventions. Assumptions were made regarding risk adjustment. Conclusions and future work: Results suggest the burden of pilonidal surgery is greater than reported previously. This can be mitigated with better selection of intervention according to disease type and patient desired goals. Results indicate a framework for future higher-quality trials that stratify disease and utilise broad groupings of common interventions with development of a patient-centred core outcome set. Trial registration: This trial is registered as ISRCTN95551898. Funding: This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 17/17/02) and is published in full in

Indexed as

Pilonidal SinusAdolescentAdultDelphi TechniqueFemaleHumansMaleMiddle AgedPatient PreferencePostoperative PainProspective StudiesRecurrenceSeverity of Illness IndexUnited KingdomWound HealingYoung AdultCOHORT STUDIESHEALTH CAREOUTCOME ASSESSMENTPATIENT ACUITYPILONIDAL DISEASEPROPENSITY SCORE

Identifiers

PMID39045854
PMCPMC11284621

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.