Evidence map›Paper›PMID 39045554›Full record

ArticleFrontiers in psychiatry2024

Case report: Tremor in the placebo condition of a blinded clinical trial of intermittent theta-burst stimulation for cocaine use disorder.

Vaughn R Steele, Alexander Rotenberg, Noah S Philip, Mark Hallett, Elliot A Stein, Betty Jo Salmeron

Registry-linked trialAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02927236 (Neuroplasticity Following Theta-Burst Stimulation in Cocaine Use Disorder), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02927236 naterminatednot on this map

Neuroplasticity Following Theta-Burst Stimulation in Cocaine Use Disorder

TypeinterventionalSponsorNational Institute on Drug Abuse (NIDA)Ran2017 to 2023Enrolled45ConditionsCocaine Use Disorder, Cocaine DependenceArmsTranscranial magnetic stimulation (TMS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vaughn R SteeleDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, United States.
Alexander RotenbergDepartment of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Noah S PhilipDepartment of Psychiatry and Human Behavior, The Warren Alpert Medical School, Brown University, Providence, RI, United States.
Mark HallettNational Institute of Neurological Disorders and Stroke, Intramural Research Program, National Institutes of Health, Bethesda MD, United States.
Elliot A SteinNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.
Betty Jo SalmeronNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Baltimore, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a new-onset, persistent tremor that developed during a clinical trial (NCT02927236) of intermittent theta burst stimulation [iTBS, a form of repetitive magnetic transcranial magnetic stimulation (rTMS)] for cocaine use disorder. Although the participant exhibited an exceptionally strong clinical response, subsequent unblinding revealed that they received sham iTBS. This case highlights the potential for strong functional neurological placebo responses in rTMS trials, and functional disorders might be a marker of a placebo response. Additionally, we note the possibility that the weak e-fields produced by some sham rTMS systems may induce clinically relevant effects.

Indexed as

cocaine use disorderiTBSlow-intensity rTMSplacebo effectsham rTMS

Identifiers

PMID39045554
PMCPMC11263940

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.