ArticleEClinicalMedicine2024
Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts.
Article in EClinicalMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between maternal multimorbidity and preterm birth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study.BMJ open · 2025Trial
- Validation of an Algorithmic Pipeline for Wrist-Worn Devices to Estimate Walking Speed in People with Multiple Long-Term Conditions.Sensors (Basel, Switzerland) · 2026Article
- Life-course patterning of MLTC clusters and their patient-centred burden in depression: a population-based study using real-world data.BMJ mental health · 2026Article
- The kidney failure risk equation in people with CKD and multimorbidity: the effect of competing mortality risks.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Observational
- Article
- Ten-year population-based assessment of multimorbidity burden progression in a regional cohort of 5.5 million adults.NPJ digital medicine · 2026Article
- Who is providing pain care? Mapping chronic pain services across Scotland using freedom of information requests.British journal of pain · 2026Article
- Multimorbidity and its associations with physical function, fall risk, and hospitalization cost in adults with type 1 diabetes: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Patterns of comorbidities, clinical course, and impact of the ABC Pathway for Integrated Care in patients with atrial fibrillation: a report from the prospective Optimal Thromboprophylaxis in Elderly Chinese Patients with Atrial Fibrillation (ChiOTEAF) Registry.European heart journal. Quality of care & clinical outcomes · 2025Article
- Clusters of Comorbidities in Multiple Sclerosis and Their Influence on Healthcare Resource Usage.European journal of neurology · 2025Observational
- Measuring individual and community capacity factors in people with multimorbidity and exploring associations with health outcomes.BMC medicine · 2025Article
- Identifying predictors of medication-related harm in older populations: a latent class analysis approach.Age and ageing · 2025Article
- Extrahepatic disease clusters and mortality in people with steatotic liver diseases: a prospective analysis of 64,749 females and 113,587 males in the UK Biobank.BMC medicine · 2025Article
- Development and evaluation of an integrated multispecialty clinic for people with multiple long-term conditions.Future healthcare journal · 2025Article
- Multimorbidity patterns in older adults from Northern Netherlands: comparing factor analysis and latent class analysis solutions.BMC geriatrics · 2025Article
- Multiple long-term conditions as the next transition in the global diabetes epidemic.Communications medicine · 2025Review
- Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts.BMC medicine · 2025Article
- Clustering of behavioral and chronic health risk factors and their association with self-reported health and cardiovascular disease outcome among adults in North Carolina.AIMS public health · 2025Article
- Associations of built environment features with multimorbidity: A systematic review protocol.Journal of multimorbidity and comorbidityArticle
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Authors and funding
26 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: It remains unclear how to meaningfully classify people living with multimorbidity (multiple long-term conditions (MLTCs)), beyond counting the number of conditions. This paper aims to identify clusters of MLTCs in different age groups and associated risks of adverse health outcomes and service use. Methods: Latent class analysis was used to identify MLTCs clusters in different age groups in three cohorts: Secure Anonymised Information Linkage Databank (SAIL) (n = 1,825,289), UK Biobank (n = 502,363), and the UK Household Longitudinal Study (UKHLS) (n = 49,186). Incidence rate ratios (IRR) for MLTC clusters were computed for: all-cause mortality, hospitalisations, and general practice (GP) use over 10 years, using <2 MLTCs as reference. Information on health outcomes and service use were extracted for a ten year follow up period (between 01 Findings: Clustering MLTCs produced largely similar results across different age groups and cohorts. MLTC clusters had distinct associations with health outcomes and service use after accounting for LTC counts, in fully adjusted models. The largest associations with mortality, hospitalisations and GP use in SAIL were observed for the " Interpretation: Personalising care around MLTC clusters that have higher risk of adverse outcomes may have important implications for practice (in relation to secondary prevention), policy (with allocation of health care resources), and research (intervention development and targeting), for people living with MLTCs. Funding: This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)-NIHR202020).
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