The Role of Extracellular Vesicles in the Skin and Their Interactions with Nanoparticles.

Francesca Agobe, Lisa A DeLouise

Abstract read

In one paragraph

Article in World journal of nanoscience and nanotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Francesca AgobeDepartment of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.

Lisa A DeLouiseDepartment of Dermatology, University of Rochester Medical Center, Rochester, New York, USA.

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI Sally W Thurston · 1985 to 2026

$42.8M

Quantifying Risk Factors for Nanoparticle Contact with UVB Exposed SkinR01ES021492 · NIEHS · UNIVERSITY OF ROCHESTER · PI DELOUISE, LISA A · 2012 to 2022

$3.5M

NIEHS NIH HHS P30 ES001247NIEHS NIH HHS R01 ES021492

6 · The paper itself

Abstract

Extracellular vesicles (EVs) include exosomes and microvesicles. They are released from cells under both physiological and pathological conditions. EVs can be isolated from a host of biological mediums, such as blood plasma, saliva, and skin. The role of EVs and their contents including RNA, proteins, and signaling molecules, depends on the specific cells and organs from which they are derived and diseased state. EVs play a key role in cell-to-cell communication. Although the role of EVs in skin biology is a developing field, recent literature suggests they play an important role in skin homeostasis, disease, and transdermal drug delivery. EVs have been shown to modulate skin pigmentation, and aid in the cutaneous wound healing process and the secretion of nanoparticles. This paper reviews the basics of EV biogenesis, their isolation and their role in skin. We also review what is currently known about how nanoparticles may impact the contents of EVs in the skin.

Identifiers

PMID39045530

PMCPMC11265537

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.