Evidence map›Paper›PMID 39045421›Full record

ReviewResearch (Washington, D.C.)2024

Nano-Assisted Radiotherapy Strategies: New Opportunities for Treatment of Non-Small Cell Lung Cancer.

Lihong Zhao, Mei Li, Chen Shen, Yurui Luo, Xiaoming Hou, Yu Qi, Ziwei Huang, Wei Li, Lanyang Gao, Min Wu and 1 more

Abstract readReview
In one paragraph

Review in Research (Washington, D.C.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lihong ZhaoWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0009-0006-5625-5469
Mei LiWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0001-9868-951X
Chen ShenWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0002-0306-7476
Yurui LuoWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0009-0008-1032-2931
Xiaoming HouWest China Hospital, Sichuan University, Chengdu 610041, China.
Yu QiWest China Hospital, Sichuan University, Chengdu 610041, China.
Ziwei HuangWest China Hospital, Sichuan University, Chengdu 610041, China.
Wei LiWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0003-2258-5516
Lanyang GaoThe Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, China.ORCID https://orcid.org/0000-0001-9211-8468
Min WuWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0002-7733-2498
Yao LuoWest China Hospital, Sichuan University, Chengdu 610041, China.ORCID https://orcid.org/0000-0002-4542-3504

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is the second most commonly diagnosed cancer and a leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the most prevalent type. Over 70% of lung cancer patients require radiotherapy (RT), which operates through direct and indirect mechanisms to treat cancer. However, RT can damage healthy tissues and encounter radiological resistance, making it crucial to enhance its precision to optimize treatment outcomes, minimize side effects, and overcome radioresistance. Integrating nanotechnology into RT presents a promising method to increase its efficacy. This review explores various nano-assisted RT strategies aimed at achieving precision treatment. These include using nanomaterials as radiosensitizers, applying nanotechnology to modify the tumor microenvironment, and employing nano-based radioprotectors and radiation-treated cell products for indirect cancer RT. We also explore recent advancements in nano-assisted RT for NSCLC, such as biomimetic targeting that alters mesenchymal stromal cells, magnetic targeting strategies, and nanosensitization with high-atomic number nanomaterials. Finally, we address the existing challenges and future directions of precision RT using nanotechnology, highlighting its potential clinical applications.

Identifiers

PMID39045421
PMCPMC11265788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.