Evidence map›Paper›PMID 39045393›Full record

ArticleJID innovations : skin science from molecules to population health2024

Coencapsulation of Immunosuppressive Drug with Anti-Inflammatory Molecule in Pickering Emulsions as an Innovative Therapeutic Approach for Inflammatory Dermatoses.

Maxime Sintès, Petra Kovjenic, Liasmine Haine Hablal, Kevin Serror, Mohamed Beladjine, Véronique Parietti Montcuquet, Marine Delagrange, Bertrand Ducos, Jean-David Bouaziz, David Boccara and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Maxime SintèsInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.
Petra KovjenicUniversity Paris Saclay, CNRS, Institut Galien Paris-Saclay, Orsay, France.
Liasmine Haine HablalInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.
Kevin SerrorDepartment of Reconstructive and Plastic Surgery, Hôpital Saint-Louis, Paris, France.
Mohamed BeladjineUniversity Paris Saclay, CNRS, Institut Galien Paris-Saclay, Orsay, France.
Véronique Parietti MontcuquetParis Cité University, INSERM/CNRS, US53/UAR2030, Institut de Recherche Saint-Louis, Paris, France.
Marine DelagrangeHigh Throughput qPCR Core Facility, École Normale Supérieure, Université Paris Sciences & Lettres, Paris, France.
Bertrand DucosHigh Throughput qPCR Core Facility, École Normale Supérieure, Université Paris Sciences & Lettres, Paris, France.
Jean-David BouazizInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.
David BoccaraDepartment of Reconstructive and Plastic Surgery, Hôpital Saint-Louis, Paris, France.
Maurice MimounDepartment of Reconstructive and Plastic Surgery, Hôpital Saint-Louis, Paris, France.
Armand BensussanInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.
Martine BagotInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.
Nicolas HuangUniversity Paris Saclay, CNRS, Institut Galien Paris-Saclay, Orsay, France.
Laurence MichelInserm UMR_U976, University Paris Cité, Skin Research Center, Hôpital Saint-Louis, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is an inflammatory skin disease characterized by epidermal and immune dysfunctions. Although efficient, current topical treatments display adverse effects, including skin atrophy and burning sensation, leading to poor patient adherence. To overcome these downsides, pickering emulsions were formulated in which the calcitriol-containing dispersed phase was stabilized with either cyclosporin A- or tacrolimus-loaded poly(lactic-co-glycolic) acid nanoparticles. This study aimed to investigate their biological effects on lymphocytes and epidermal cells and their effectiveness in an imiquimod-induced psoriasis-like mouse model. Results showed that both emulsions significantly inhibited nuclear factor of activated T cell translocation in T lymphocytes as well as their IL-2 production, cell activation, and proliferation. In keratinocytes, inhibition of nuclear factor of activated T cell translocation decreased the production of IL-8 and TNF-α. Topical application of emulsions over skin biopsies ex vivo showed accumulation of rhodamin B-coupled poly(lactic-co-glycolic) acid nanoparticles throughout the epidermis by immunofluorescence and significantly decreased the antigen-presenting capacity of Langerhans cells in relation to a reduced expression of activation markers CD40, CD86, and HLA-DR. Using an imiquimod-induced psoriasis model in vivo, pickering emulsions significantly alleviated psoriasiform lesions potentially attributed to the decreased cutaneous expression of T-cell markers, proinflammatory cytokines, chemokines, and specific epidermal cell genes. Altogether, pickering emulsion might be a very efficient formulation for treating inflammatory dermatoses.

Indexed as

CoencapsulationInflammatory dermatosesNanoparticlesPickering emulsionsPsoriasis

Identifiers

PMID39045393
PMCPMC11264173

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.