ReviewFrontiers in endocrinology2024
Childhood obesity from the genes to the epigenome.
Review in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Independent and synergistic effects of maternal and paternal obesogenic diets on offspring early-life outcomes in the rat.Experimental physiology · 2026Article
- The obesity-brain axis: a comprehensive review of neurological complications and therapeutic interventions in metabolic syndrome.Diabetology & metabolic syndrome · 2026Review
- From Risks to Roots: The Multifactorial Etiopathogenesis of Childhood Obesity.International journal of molecular sciences · 2026Review
- Childhood Obesity: Global Burden, Multifactorial Etiologies, Biological Mechanisms, and Emerging Interventions for Prevention and Management.Saudi medical journal · 2026Review
- Development and external validation of an interpretable machine learning-based model for obesity risk prediction in 2-18-year-old children and adolescents in Beijing and Tangshan.Journal of global health · 2026Article
- Paternal transgenerational epigenetic effects: high fat diet induced obesity alters miRNA expression in F1 and F2 C57BL/6 male mice.Molecular genetics and genomics : MGG · 2025Article
- Metaflammation's Role in Systemic Dysfunction in Obesity: A Comprehensive Review.International journal of molecular sciences · 2025Review
- Review
- When Genes Wear Marks: Epigenomic Modulation in the Development and Progression of Obesity.International journal of molecular sciences · 2025Review
- Article
- Childhood Obesity: A Narrative Review.Cureus · 2025Review
- Longitudinal Analysis of PlacentalInternational journal of molecular sciences · 2025Article
- Environmental and social determinants of cardiovascular risk in women with type 2 diabetes: a life-course perspective.Frontiers in endocrinology · 2025Review
- Normal weight obesity in adolescents: patterns and associated factors.Frontiers in nutrition · 2025Article
- Genetic Landscape of Obesity in Children: Research Advances and Prospects.Journal of obesity · 2025Review
- Review
- Obesity in children: inheritance and treatment - state of art 2024.Pediatric endocrinology, diabetes, and metabolism · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The prevalence of obesity and its associated comorbidities has surged dramatically in recent decades. Especially concerning is the increased rate of childhood obesity, resulting in diseases traditionally associated only with adulthood. While obesity fundamentally arises from energy imbalance, emerging evidence over the past decade has revealed the involvement of additional factors. Epidemiological and murine studies have provided extensive evidence linking parental obesity to increased offspring weight and subsequent cardiometabolic complications in adulthood. Offspring exposed to an obese environment during conception, pregnancy, and/or lactation often exhibit increased body weight and long-term metabolic health issues, suggesting a transgenerational inheritance of disease susceptibility through epigenetic mechanisms rather than solely classic genetic mutations. In this review, we explore the current understanding of the mechanisms mediating transgenerational and intergenerational transmission of obesity. We delve into recent findings regarding both paternal and maternal obesity, shedding light on the underlying mechanisms and potential sex differences in offspring outcomes. A deeper understanding of the mechanisms behind obesity inheritance holds promise for enhancing clinical management strategies in offspring and breaking the cycle of increased metabolic risk across generations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.