Evidence map›Paper›PMID 39045138›Full record

ArticleMetabolism open2024

Seasonal variation and Vitamin-D status in ostensibly healthy Indian population: An experience from a tertiary care institute.

Karli Sreenivasulu, Mithu Banerjee, Sojit Tomo, Kamalkant Shukla, Maithili Karpaga Selvi, Mahendra Kumar Garg, Sumit Banerjee, Praveen Sharma, Ravindra Shukla

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Article in Metabolism open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Karli SreenivasuluDepartment of Biochemistry, Alluri Sitarama Raju Academy of Medical Sciences, Eluru, India.
Mithu BanerjeeDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Sojit TomoDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Kamalkant ShuklaDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Maithili Karpaga SelviDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Mahendra Kumar GargDepartment of Medicine, All India Institute of Medical Sciences, Jodhpur, India.
Sumit BanerjeeDepartment of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, India.
Praveen SharmaDepartment of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India.
Ravindra ShuklaDepartment of Endocrinology, All India Institute of Medical Sciences, Jodhpur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: 25-hydroxy vitamin-D (25(OH)D) deficiency is prevalent worldwide including India. Earlier some cross-sectional studies have discussed 25(OH)D deficiency and its prevalence. The correlation of 25(OH)D with seasonal variation has been reported rarely in India. To determine the 25(OH)D levels and seasonal changes of 25(OH)D status at a tertiary care hospital in North-western India. Materials and methods: 25(OH)D assessments performed in laboratories between 2018 and 2020 was acquired using hospital records. A total of 11,428 assays of serum 25(OH)D were analyzed in the study. Subjects were divided into three groups based on the International Endocrine Society's recommendation for serum 25(OH)D level. The 25(OH)D deficiency <20 ng/ml, insufficiency 20-29 ng/mL and sufficiency ≥30 ng/mL was defined. The months have been separated into the following seasons to analyze seasonal trends: Summer/monsoon (April-September), and winter/spring (October-March). Results: The median 25(OH)D was 17.2 ng/mL. We observed the prevalence of 60 %, 24.1 % & 15.9 % of 25(OH)D deficiency, 25(OH)D insufficiency, and sufficiency respectively in the total number of individuals tested. 56 % male and 63 % females were 25(OH)D deficient. Notably, the lowest median 25(OH)D value was found in the 21-30 age group (14.8 ng/mL). A significant difference in 25(OH)D levels between the summer (18.7 ng/mL) and winter (15.8 ng/mL) seasons has been noticed. Discussion: Current study revealing that 25(OH)D deficiency is common in all age groups and genders, according to our findings. Surprisingly, the lowest levels were reported in young adults. Seasonal variation has an impact on 25(OH)D status, however in all seasons 25(OH)D levels are lower than reference intervals. These findings suggest that the criteria for determining the state of 25(OH)D insufficiency and deficiency in the Indian population should be reconsidered.

Indexed as

25-Hydroxy Vitamin-DSeasonal variationVitamin-D deficiency

Identifiers

PMID39045138
PMCPMC11263621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.