Evidence map›Paper›PMID 39045105›Full record

ArticleiScience2024

The ATP-exporting channel Pannexin 1 promotes CD8

Trupti Vardam-Kaur, Alma Banuelos, Maria Gabaldon-Parish, Bruna Gois Macedo, Caio Loureiro Salgado, Kelsey Marie Wanhainen, Maggie Hanqi Zhou, Sarah van Dijk, Igor Santiago-Carvalho, Angad S Beniwal and 5 more

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The C-terminal activating domain promotes pannexin 1 channel opening.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Review
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Trupti Vardam-KaurDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Alma BanuelosDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Maria Gabaldon-ParishDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Bruna Gois MacedoDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Caio Loureiro SalgadoDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Kelsey Marie WanhainenCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Maggie Hanqi ZhouDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Sarah van DijkDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Igor Santiago-CarvalhoDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Angad S BeniwalDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Chloe L LeffDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Changwei PengCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Nhan L TranDepartment of Cancer Biology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.
Stephen C JamesonCenter for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Henrique Borges da SilvaDepartment of Immunology, Mayo Clinic Arizona, Scottsdale, AZ 85255, USA.

Funding

Regulation of T cell responses by P2RX7R01AI145147 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2019 to 2023
$3.3M
Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4M
DEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITYR00AI139381 · NIAID · MAYO CLINIC ARIZONA · PI BORGES DA SILVA, HENRIQUE · 2020 to 2021
$498k
NIAID NIH HHS R00 AI139381NIAID NIH HHS R01 AI145147NIAID NIH HHS R01 AI170649
6 · The paper itself

Abstract

Sensing of extracellular ATP (eATP) controls CD8

Indexed as

BiochemistryBiological sciencesImmune responseImmune systemImmunologyNatural sciences

Identifiers

PMID39045105
PMCPMC11263643

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.