Evidence map›Paper›PMID 39045100›Full record

ArticleiScience2024

Inhibiting retinoic acid signaling in dendritic cells suppresses respiratory syncytial virus infection through enhanced antiviral immunity.

Mohammad Farazuddin, Grant Acker, Joseph Zourob, Jessica J O'Konek, Pamela T Wong, Susan Morris, Andrew J Rasky, Chang H Kim, Nicholas W Lukacs, James R Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Retinoic acid in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
  3. Immune cell disorder in viral pneumonia.Journal of translational medicine · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad FarazuddinDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Grant AckerMichigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI, USA.
Joseph ZourobMichigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, MI, USA.
Jessica J O'KonekDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Pamela T WongDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.
Susan MorrisMary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew J RaskyMary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Chang H KimMary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA.
Nicholas W LukacsMary H. Weiser Food Allergy Center, University of Michigan Medical School, Ann Arbor, MI, USA.
James R BakerDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoic acid (RA), controls the immunoregulatory functions of many immune cells, including dendritic cells (DCs), and is important for mucosal immunity. In DCs, RA regulates the expression of pattern recognition receptors and stimulates interferon production. Here, we investigated the role of RA in DCs in mounting immunity to respiratory syncytial virus (RSV). To abolish RA signaling in DCs, we used mice expressing a dominant negative form of retinoic acid receptor-α (RARα) under the CD11c promoter (CD11c-dnRARα). Paradoxically, upon RSV challenge, these animals had lower viral burden, reduced pathology, and greater Th1 polarized immunity than wild-type (WT) mice. Moreover, CD11c-dnRARα DCs infected with RSV showed enhancement in innate and adaptive immunity genes, while genes associated with viral replication were downregulated. These findings suggest that the absence of RA signaling in DCs enhances innate immunity against RSV infection leading to decreased viral load and reduced pathogenicity.

Indexed as

cell biologyImmunologyVirology

Identifiers

PMID39045100
PMCPMC11263793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.