ArticleCureus2024
D-dimer as a Useful Biomarker in Early Diagnosis of Neonatal Sepsis: A Single-Center Study From Romania.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Role of plasma D-dimer levels as diagnostic and prognostic marker in neonatal sepsis: An insightful support.World journal of clinical pediatrics · 2026Article
- Persistent SARS-CoV-2 Positive Tests in Neonates: Clinical Outcomes, Transmission Pathways, and Immune Vulnerability-Case Series.Children (Basel, Switzerland) · 2026Article
- Maternal prothrombin time as an independent predictor of neonatal sepsis: A retrospective case-control study.PloS one · 2026Article
- An Epidemiological Survey of Sepsis in a Tertiary Academic Hospital from Southwestern Romania.Medicina (Kaunas, Lithuania) · 2025Article
- Systematic Review: Maternal Risk Factors, Socioeconomic Influences, Neonatal Biomarkers and Management of Early-Onset Sepsis in Late Preterm and Term Newborns-A Focus on European and Eastern European Contexts.Life (Basel, Switzerland) · 2025Review
- Strength of Omics in Uncovering Sepsis Mechanisms-A Perspective.Current health sciences journalReview
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Authors and funding
11 authors.
Funding
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Abstract
backgroundThis study evaluates the role of D-dimer in identifying neonatal sepsis and their potential value in clinical decision-making due to challenges in early detection. METHODOLOGY: A case-control study was conducted on 102 neonates at the Children's Clinical Hospital "Louis Turcanu" in Timisoara, Romania, from October 2018 to July 2023. The participants were divided into two groups: those with neonatal sepsis and those without sepsis.
resultsThe study found that neonates with sepsis were more likely to be delivered by cesarean section and had higher rates of premature ruptured membranes compared to those without sepsis. The D-dimer biomarker's predictive value for sepsis was assessed using a receiver operating characteristic (ROC) curve, with an area under the curve (AUC) exceeding 0.982 and an optimum cutoff value of 342 ng/mL. An increase in neonatal D-dimer significantly increases the likelihood of sepsis by 2.7% per unit increase. A value above 250 ng/mL indicates a 127-fold increased likelihood of sepsis. The D-dimer's ability to predict mortality in newborns with sepsis is unsatisfactory, with an AUC of 0.528.
conclusionsD-dimer, a potential biomarker of neonatal sepsis, warrants further clinical investigation to enhance diagnostic sensitivity and specificity, demonstrating its potential in conjunction with other sepsis markers.
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