ArticleEuropean heart journal. Imaging methods and practice2023
Pericardial late gadolinium enhancement and time to recurrence: a substudy from RHAPSODY, a phase 3 clinical trial of rilonacept in recurrent pericarditis.
Article in European heart journal. Imaging methods and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase 3, Double-Blind, Placebo-Controlled, Randomized Withdrawal Study With Open-label Extension, to Assess the Efficacy and Safety of Rilonacept Treatment in Subjects With Recurrent Pericarditis
Serial Cardiac Magnetic Resonance Imaging for Guidance of Therapy Management in Patients Treated With Anakinra Due to Recurrent Pericarditis
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pericardial Diseases: International Position Statement on New Concepts and Advances in Multimodality Cardiac Imaging.JACC. Cardiovascular imaging · 2024Guideline
- Longitudinal cardiac magnetic resonance imaging following clinical response to rilonacept and prior to recurrence upon treatment suspension: a RHAPSODY subgroup analysis.European heart journal. Cardiovascular Imaging · 2024Trial
- Sustained Pericarditis Recurrence Risk Reduction With Long-Term Rilonacept.Journal of the American Heart Association · 2024Trial
- Recurrent Pericarditis in a Rugby Player: Imaging-Guided Therapy.JACC. Case reports · 2026Article
- Pericarditis in Systemic Lupus Erythematosus: A Comprehensive Review of Pathogenesis, Diagnosis, and Management.Cureus · 2026Review
- Relapsing Pericarditis: Prediction of Relapses, Risk Scores, and Role of Exercise Restriction.Methodist DeBakey cardiovascular journal · 2026Review
- Role of Cardiac MRI and CT in Pericarditis and Pericardial Constriction.Methodist DeBakey cardiovascular journal · 2026Review
- Autoimmune Pericarditis: Diagnosis and New Therapeutics.Current cardiology reports · 2025Review
- Recurrent Acute Pericarditis Complicated by Constriction in T-Cell Acute Lymphoblastic Leukemia: Role of Multimodality Imaging.JACC. Case reports · 2025Article
- Review
- Advances in the Multimodality Imaging and Management of Recurrent Pericarditis: A Contemporary Review.Current cardiology reports · 2024Review
- Recurrent Pericarditis and Paradigm Shift in Cardiovascular Imaging and Targeted Therapeutics.JACC. Advances · 2024Review
- Beware the glowing fat: pericarditis pitfall.European heart journal. Imaging methods and practice · 2024Article
- Serial cardiac magnetic resonance imaging for guidance of therapy management in patients treated with anakinra due to recurrent pericarditis.European heart journal. Imaging methods and practice · 2024Article
- Celebrating 1 year ofEuropean heart journal. Imaging methods and practice · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims: In this protocol-predefined substudy of the RHAPSODY trial, the primary aim was to assess whether pericardial late gadolinium enhancement (LGE) was associated with time to pericarditis recurrence. Methods and results: RHAPSODY was a Phase 3 double-blind, placebo-controlled, randomized-withdrawal trial that demonstrated the efficacy of rilonacept in recurrent pericarditis (RP). Patients with a history of multiple RP and an active recurrence were enrolled and had the option to participate in a cardiac magnetic resonance (CMR) imaging substudy. CMRs were interpreted by a blinded independent core laboratory with prespecified criteria to define pericardial LGE. Compared to patients with trace or mild pericardial LGE ( Conclusions: Among patients with multiple RP, these preliminary findings support the concept of pericardial LGE as an imaging biomarker that may inform the duration of treatment and risk of recurrence with cessation of therapy and larger studies should be considered. ClinicalTrialsgov Identifier: NCT03737110.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.