Evidence map›Paper›PMID 39044631›Full record

Trial reportPharmacology research & perspectives2024

Bioequivalence study of low dose drospirenone/ethinyl estradiol 3 mg/0.03 mg film tablets under fasting conditions in Turkish healthy female subjects.

Ahmet Inal, Zafer Sezer, Berna Uluözlü, Melih Oflas, Martin Reinsch, Wolfgang Martin, Mümtaz M Mazicioglu, Selma Alime Koru

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Pharmacology research & perspectives, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ahmet InalErciyes University Faculty of Medicine, Department of Pharmacology and Erciyes University Good Clinical Practice and Research Center, Kayseri, Turkey.ORCID 0000-0002-5917-3729
Zafer SezerErciyes University Faculty of Medicine, Department of Pharmacology and Erciyes University Good Clinical Practice and Research Center, Kayseri, Turkey.ORCID 0000-0003-4858-3906
Berna UluözlüBiofarma İlaç Sanayi ve Ticaret A.Ş, İstanbul, Turkey.ORCID 0009-0003-9358-6521
Melih OflasBiofarma İlaç Sanayi ve Ticaret A.Ş, İstanbul, Turkey.ORCID 0009-0001-9432-6268
Martin ReinschAnalytisches Zentrum Biopharm GmbH, Berlin, Germany.ORCID 0009-0009-2643-1398
Wolfgang MartinPharmakin Consulting Services UG, Neu-Ulm, Germany.ORCID 0009-0004-0862-9396
Mümtaz M MaziciogluErciyes University Faculty of Medicine, Department of Family Medicine and Erciyes University Good Clinical Practice and Research Center, Kayseri, Turkey.ORCID 0000-0002-6458-2906
Selma Alime KoruIdeal Contract Research Organisation, Ankara, Turkey.ORCID 0009-0008-3959-9889

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This bioequivalence research aims to evaluate the relative bioavailability and pharmacokinetic characteristics of ethinyl estradiol and drospirenone in the test preparation in comparison to the reference preparation during fasting conditions. A liquid chromatography method with tandem mass spectrometry was used to determine the concentrations of drospirenone and ethinyl estradiol in plasma. The pharmacokinetic parameters that were analyzed were the maximum plasma concentration (C

Indexed as

AndrostenesArea Under CurveEthinyl EstradiolFastingTabletsTherapeutic EquivalencyAdultBiological AvailabilityCross-Over StudiesDrug CombinationsFemaleHalf-LifeHealthy VolunteersHumansTandem Mass SpectrometryYoung AdultAndrostenesdrospirenonedrospirenone and ethinyl estradiol combinationDrug CombinationsEthinyl EstradiolTabletsbioavailabilityBioequivalance studylow dose drospirenonelow dose ethynil estradiolpharmacokinetic

Identifiers

PMID39044631
PMCPMC11266778

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.