Evidence map›Paper›PMID 39044087›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Production and Purification of Adeno-Associated Viral Vectors for the Development of Immune-Competent Mouse Models of Persistent Hepatitis B Virus Replication.

Lisa Schiller, Chunkyu Ko, Anna D Kosinska, Dirk Grimm, Ulrike Protzer

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lisa SchillerInstitute of Virology, Technical University of Munich, School of Medicine/Helmholtz Munich, Munich, Germany.
Chunkyu KoInfectious Diseases Therapeutic Research Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon, Republic of Korea.
Anna D KosinskaInstitute of Virology, Technical University of Munich, School of Medicine/Helmholtz Munich, Munich, Germany.
Dirk GrimmGerman Center for Infection Research (DZIF), partner sites, Munich and Heidelberg, Germany.
Ulrike ProtzerInstitute of Virology, Technical University of Munich, School of Medicine/Helmholtz Munich, Munich, Germany. protzer@tum.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice infected with a recombinant adeno-associated virus carrying a replication-competent hepatitis B virus genome (rAAV-HBV) via the intravenous route establish a persistent HBV replication in hepatocytes and develop immune tolerance. They serve as models to evaluate antiviral immunity and to assess potential therapeutic approaches for chronic HBV infection. Combining selected HBV variants and different mouse genotypes allows for addressing a broad spectrum of research questions. This chapter describes the basic principles of the rAAV-HBV mouse model, rAAV-HBV production and purification methods, and finally, the in vivo application.

Indexed as

DependovirusDisease Models, AnimalGenetic VectorsHepatitis B virusVirus ReplicationAnimalsHepatitis BHepatitis B, ChronicHumansMiceAdeno-associated virusCchronic HBV infectionGene transferHBV variantsHepatitis B virusIodixanol purificationMouse model

Identifiers

PMID39044087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.