Evidence map›Paper›PMID 39044071›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Primary Duck Hepatocyte Culture and Duck Hepatitis B Virus Infection Model.

Jisu Li, Shuping Tong

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jisu LiLiver Research Center, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI, USA. Ji_Su_Li_md@brown.edu.
Shuping TongLiver Research Center, Rhode Island Hospital and Warren Alpert Medical School of Brown University, Providence, RI, USA.

Funding

Explore furin as an antiviral target to block hepatitis B virus e antigen productionR21AI166875 · NIAID · RHODE ISLAND HOSPITAL · PI TONG, SHUPING · 2021 to 2022
$451k
Post-translational regulation of hepatitis B virus large envelope proteinR21AI163819 · NIAID · RHODE ISLAND HOSPITAL · PI LI, JISU · 2021 to 2022
$451k
NIAID NIH HHS R21 AI163819NIAID NIH HHS R21 AI166875
6 · The paper itself

Abstract

Duck hepatitis B virus (DHBV) is an avian member of the hepatotropic DNA viruses, or hepadnaviridae. It shares with the human hepatitis B virus (HBV) a similar genomic organization and replication strategy via reverse transcription, but is simpler than HBV in lacking the X gene and in expressing just two coterminal envelope proteins: Large (L) and small (S). DHBV has been extensively used as a convenient and valuable animal model for study of the hepadnaviral life cycle, and for drug screening in vitro but also in vivo. Ducks and primary duck hepatocytes (PDHs) are inexpensive, easily accessible, and readily infected with DHBV. The high levels of genome replication and protein expression in duck liver and PDHs also facilitate monitoring of viral life cycle using conventional molecular biology techniques such as Southern blot for replicative DNA and covalently closed circular DNA (cccDNA), Northern blot for viral RNAs, and Western blot for viral proteins.

Indexed as

DucksHepadnaviridae InfectionsHepatitis B Virus, DuckHepatocytesVirus ReplicationAnimalsCell Culture TechniquesCells, CulturedDisease Models, AnimalDNA, ViralHepatitis, Viral, AnimalPrimary Cell CultureDNA, ViralDucksIn vitro and in vivo infectionLiver perfusionPrimary duck hepatocytesTransfection

Identifiers

PMID39044071

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.