ArticleNature aging2024
An NAD
Abstract read
In one paragraph
Article in Nature aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review.Frontiers in immunology · 2025Pooled it
- A sustained NADBioactive materials · 2026Article
- Cell-Type-Specific Calibration of Mitochondrial Ubiquitination in Stem Cell Fate Decisions.Stem cell reviews and reports · 2026Review
- Hematopoietic Stem Cell Metabolism during Stress and Aging.Advances in geriatric medicine and research · 2026Article
- Article
- Trained immunity links hematopoietic stem cell aging to aging-associated inflammation.Nature aging · 2026Article
- PFKM acts as a metabolic switch initiating donut-shaped mitochondrial remodeling to promote osteogenesis.International journal of oral science · 2026Article
- Improving lymphopoiesis in aged bone marrow.Current opinion in hematology · 2026Review
- Hematopoietic Aging and Leukemia: Mechanistic and Therapeutic Insights.International journal of molecular sciences · 2026Review
- Review
- Intrinsic and niche-dependent metabolic regulation of haematopoietic stem cells and implications for leukaemogenesis.Nature cell biology · 2026Review
- METTL3-mediated mMolecular cancer · 2026Article
- Squishing, squeezing and stretching age hematopoietic stem cells.Nature aging · 2026Article
- Lessons in longevity from blood stem cells under protein stress.Trends in cell biology · 2026Review
- Regulating the regulators via targeting CD38 in the tumor microenvironment.Frontiers in immunology · 2026Review
- Metabolic adaptation of regenerative hematopoiesis depends on docking-independent mitochondrial connexin 43.Blood · 2025Article
- Hematopoietic Stem Cell Aging: Mechanisms, Microenvironment Influences, and Rejuvenation Strategies.Bioengineering (Basel, Switzerland) · 2025Review
- SIRT2 and NADAging cell · 2025Article
- Haematopoietic ageing in health and lifespan.Nature cell biology · 2025Review
- Restoring resident tissue macrophages to combat aging and cancer.Nature aging · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Zehan SongDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Sang Hee ParkDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Wei-Chieh MuDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-2669-7312
Yufan FengDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Chih-Ling WangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Yifei WangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Marine BarthezDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Ayane MaruichiDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Jiayue GuoDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Fanghan YangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA.
Anita Wong LinCancer Research Laboratory, University of California, Berkeley, CA, USA.
Kartoosh HeydariCancer Research Laboratory, University of California, Berkeley, CA, USA.
Claudia C S ChiniMetabolism and Molecular Nutrition Laboratory, Kogod Center on Aging, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Jacksonville, FL, USA.
Eduardo N ChiniMetabolism and Molecular Nutrition Laboratory, Kogod Center on Aging, Department of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0003-1555-4834
Cholsoon JangDepartment of Biological Chemistry, University of California, Irvine, CA, USA.
Danica ChenDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, CA, USA. danicac@berkeley.edu.ORCID http://orcid.org/0000-0001-9169-4973
Funding
The Sir2-p53-IGF Link in Mammalian Life-Span ControlR01AG026094 · NIA · UNIVERSITY OF VIRGINIA · PI CHINI, EDUARDO N · 2006 to 2016
$3.8MTherapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0MCD38 modulation of NAD metabolism driving scleroderma pathogenesisR01AR081788 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eduardo N Chini, John Varga · 2023 to 2026
$2.6MElucidating dietary fructose and alcohol interactions during liver cancer developmentR01AA029124 · NIAAA · UNIVERSITY OF CALIFORNIA-IRVINE · PI JANG, CHOLSOON · 2021 to 2025
$2.0MRole of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0MInflammation and Aging-associated DiabetesR01AG063389 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2019 to 2023
$2.0MNutrient Sensing, Hematopoietic Stem Cell Metabolism and AgingR01AG063404 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2022
$2.0MHematopoietic Stem Cell AgingR01DK117481 · NIDDK · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHEN, DANICA · 2018 to 2021
$1.7MNeural Stem Cell Aging and NeurodegenerationR01AG082105 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DANICA CHEN · 2024 to 2026
$1.7MNCI NIH HHS R01 CA233790NIAAA NIH HHS R01 AA029124NIAMS NIH HHS R01 AR081788NIA NIH HHS R01 AG026094NIA NIH HHS R01 AG058812NIA NIH HHS R01 AG063389NIA NIH HHS R01 AG063404NIA NIH HHS R01 AG082105NIDDK NIH HHS R01 DK117481U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG063389U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG063404U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG082105U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AG26094U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01 AG58812U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01DK117481
Abstract
How hematopoietic stem cells (HSCs) maintain metabolic homeostasis to support tissue repair and regeneration throughout the lifespan is elusive. Here, we show that CD38, an NAD
Indexed as
ADP-ribosyl Cyclase 1AgingHematopoietic Stem CellsMitochondriaNADAnimalsCalciumCalcium ChannelsCalcium SignalingCell ProliferationCellular SenescenceMembrane GlycoproteinsMiceMice, Inbred C57BLADP-ribosyl Cyclase 1CalciumCalcium ChannelsCd38 protein, mouseMembrane Glycoproteinsmitochondrial calcium uniporterNAD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.