Evidence map›Paper›PMID 39044017›Full record

ArticleSocial psychiatry and psychiatric epidemiology2025

Decomposing the association of psychosocial wellbeing with all-cause mortality: the mediating role of physical health and lifestyle factors.

Aliya Alimujiang, Victor Strecher, Karen McLean, Alison M Mondul, Celeste Leigh Pearce, Bhramar Mukherjee

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Article in Social psychiatry and psychiatric epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Aliya AlimujiangDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Victor StrecherKumanu, Ann Arbor, MI, USA.
Karen McLeanDepartment of Health Behavior & Health Education, Director for Innovation and Social Entrepreneurship, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Alison M MondulDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Celeste Leigh Pearce *Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA. lpearce@umich.edu.
Bhramar Mukherjee *Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
National Cancer Institute, US P30CA046592
6 · The paper itself

Abstract

purposeThis study quantified the effect of 48 psychosocial constructs on all-cause mortality using data from 7,698 individuals in the U.S. Health and Retirement Study.

methodsLatent class analysis was used to divide participants into mutually exclusive psychosocial wellbeing groups (good, average, or poor) which was subsequently considered as the exposure. Mediation analysis was then conducted to determine the direct effect of the psychosocial wellbeing groups and the indirect (mediating) effects of physical health (functional status and comorbid conditions) and lifestyle factors (physical activity, smoking, and alcohol consumption) on overall survival. We also created a composite health index measure representing the summative effect of the mediators.

resultsWe observed a strong and statistically significant total effect (TE) between survival time and psychosocial wellbeing group (survival time ratio (SR) = 1.73, 95% confidence interval (CI):1.50,2.01 when comparing good to poor). Mediation analysis revealed that the direct effect via psychosocial wellbeing group accounted for more than half of the TE (SR = 1.46, 95% CI:1.27,1.67). The composite health index measure mediated 36.2% of the TE with the natural indirect effect SR of 1.18 (95% CI:1.13,1.22).

conclusionOur findings demonstrate the interconnectedness between psychosocial wellbeing and physical health and lifestyle factors on survival.

Indexed as

Health StatusLife StyleMortalityAgedAlcohol DrinkingCause of DeathExerciseFemaleHumansLatent Class AnalysisMaleMediation AnalysisMiddle AgedSmokingUnited StatesLifestyle factorsMediation analysisMortalityNatural indirect effectPsychosocial wellbeing

Identifiers

PMID39044017

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.