Evidence map›Paper›PMID 39043995›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2025

Reducing the percentage of surviving infants with acute symptomatic seizures discharged on anti-seizure medication.

Anne Marie Nangle, Zhulin He, Sonam Bhalla, Jessica Bullock, Alyssa Carlson, Monideep Dutt, Shannon Hamrick, Passion Jones, Anthony Piazza, Allison Vale and 1 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anne Marie NangleDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Zhulin HePediatric Biostatistics Core, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-5852-8065
Sonam BhallaDivision of Pediatric Neurology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Jessica BullockChildren's Healthcare of Atlanta, Atlanta, GA, USA.
Alyssa CarlsonDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Monideep DuttDivision of Pediatric Neurology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Shannon HamrickDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6294-3480
Passion JonesChildren's Healthcare of Atlanta, Atlanta, GA, USA.
Anthony PiazzaDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-9714-8591
Allison ValeDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Elizabeth K SewellDivision of Neonatology, Department of Pediatrics - Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA. Elizabeth.sewell@emory.edu.ORCID http://orcid.org/0000-0003-3072-6569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the impact of inclusion of an anti-seizure medication (ASM) weaning protocol in a neonatal seizure pathway on the percent of infants discharged on ASMs. STUDY

designThis cohort study included surviving infants with acute symptomatic seizures treated with ASMs across three institutions. We evaluated infants in 2 epochs, pre- and post-implementation of the ASM weaning protocol. The primary outcome was discharge on ASM.

resultsOf 116 included infants, the percent of infants discharged on ASMs was 69% in epoch 1 versus 34% in epoch 2 (p < 0.001). There was no significant difference between epochs in recurrence of seizures after discharge by 1 year of age (p = 0.125). There was an annual decrease in the percent of infants discharged on ASM across all institutions.

conclusionInclusion of a formal ASM weaning protocol as part of an institutional seizure pathway reduced percent of infants with acute symptomatic seizures discharged on ASM.

Indexed as

AnticonvulsantsPatient DischargeSeizuresAcute DiseaseCohort StudiesFemaleHumansInfantInfant, NewbornMaleRetrospective StudiesAnticonvulsants

Identifiers

PMID39043995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.