Evidence map›Paper›PMID 39043982›Full record

ArticleNeurosurgical review2024

The difference of functional MR imaging in evaluating outcome of patients with diffuse and compact brain arteriovenous malformation.

Zheng Wen, Kaige Zheng, Shuaiwei Guo, Yang Liu, Kaiwen Wang, Qingyuan Liu, Jun Wu, Shuo Wang

Registry-linked trialAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02868008 (The Efficacy of Multimodal Magnetic Resonance Imaging Techniques in Assessing the Surgical Risk for Eloquent Arteriovenous Malformations), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02868008 naunknown statusnot on this map

The Efficacy of Multimodal Magnetic Resonance Imaging Techniques in Assessing the Surgical Risk for Eloquent Arteriovenous Malformations

TypeinterventionalSponsorBeijing Tiantan HospitalRan2016 to 2019Enrolled400ConditionsIntracranial Arteriovenous MalformationsArmsMicrosurgical resection of brain AVMs
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zheng WenDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Kaige ZhengDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Shuaiwei GuoDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Yang LiuDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Kaiwen WangDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Qingyuan LiuDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Jun WuDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China.
Shuo WangDepartment of Neurosurgery, Beijing Tiantan hospital, Capital Medical University, Beijing, China. captain9858@126.com.

Funding

National Key Research and Development Program of the 14th Five-Year Plan 2021YFC2501100
6 · The paper itself

Abstract

Microsurgical resection is an effective method to treat brain arteriovenous malformations (BAVMs). Functional magnetic resonance imaging (fMRI) can evaluate the spatial relationship of nidus and eloquent. Diffuse BAVMs are related to poor outcomes postoperatively. The role of fMRI in evaluating outcomes in patients with different nidus types remains unclear. BAVM patients received microsurgical resection were included from a prospective, multicenter cohort study. All patients underwent fMRI evaluation preoperatively and were regularly followed up postoperatively. Diffuse BAVM is radiologically identified as nidus containing normal brain tissue interspersing between malformed vessels. Lesion-to-eloquent distance (LED) was calculated based on the relationship between nidus and eloquent. The primary outcome was 180-day unfavorable neurological status postoperatively. The risk of primary outcome was investigated within different BAVM nidus types. The LED's performance to predict poor outcome was evaluated using area under curve (AUC). 346 BAVM patients were included in this study. 93 (26.9%) patients were found to have a 180-day unfavorable outcome. Multivariate logistic analysis demonstrated LED (odd ratio [OR], 0.44; 0.34-0.57; P < 0.001) and mRS at admission (OR, 2.59; 1.90-3.54; P < 0.001) as factors of unfavorable outcome. Subgroup analysis showed LED and mRS at admission as factors of unfavorable outcome for patients with compact BAVMs (all P < 0.05), but not for patients with diffuse BAVMs. Subsequent analysis showed that LED performed poorly to predict the unfavorable outcome for patients with diffuse BAVMs, compared with patients with compact BAVMs (AUC as 0.69 vs. 0.86, P < 0.05). A larger cutoff value of LED to unfavorable outcome was found in patients with diffuse BAVMs (15 mm) compared with patients with compact BAVMs (4.7 mm). Usage of LED to evaluate postoperative outcome of patients with diffuse BAVMs differs from its use in patients with compact BAVMs. Specific assessment strategy considering BAVM nidus types could help improve patients' outcome. MITASREAVM cohort (unique identifier: NCT02868008, https://clinicaltrials.gov/study/NCT02868008?term=NCT02868008&rank=1 ).

Indexed as

Intracranial Arteriovenous MalformationsMagnetic Resonance ImagingAdolescentAdultBrainFemaleHumansMaleMicrosurgeryMiddle AgedNeurosurgical ProceduresProspective StudiesTreatment OutcomeYoung AdultBrain arteriovenous malformationFunctional magnetic resonance imageOutcomeSurgery

Identifiers

PMID39043982

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.