Evidence map›Paper›PMID 39043968›Full record

ArticleActa pharmacologica Sinica2024

Adaptor protein CEMIP reduces the chemosensitivity of small cell lung cancer via activation of an SRC-YAP oncogenic module.

Xiao-Ju Shen, Hui-Lan Wei, Xiao-Cheng Mo, Xiao-Xiang Mo, Li Li, Jing-Chuan He, Xin-Yu Wei, Xiao-Jun Qin, Shang-Ping Xing, Zhuo Luo and 2 more

Abstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The crucial role of CEMIP in cancer metastasis: Mechanistic insights and clinical implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  6. Article
  7. KIAA1199: A Novel Regulator of Chemoresistance in Human Cancer Cells.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiao-Ju Shen *Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Hui-Lan Wei *Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Xiao-Cheng Mo *Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Xiao-Xiang MoDepartment of Pharmacology, Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, 530021, China.
Li LiDepartment of Pharmacology, Guangxi Institute of Chinese Medicine & Pharmaceutical Science, Nanning, 530001, China.
Jing-Chuan HeDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Xin-Yu WeiDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Xiao-Jun QinDepartment of Pharmaceutical Analysis, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Shang-Ping XingGuangxi Key Laboratory of Bioactive Molecules Research and Evaluation, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Zhuo LuoDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China. luozhuo@gxmu.edu.cn.
Zhi-Quan ChenDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China. chenzhiquan@stu.gxmu.edu.cn.
Jie YangDepartment of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China. jieyang2016@gxmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small cell lung cancer (SCLC) is a recalcitrant malignancy with dismal prognosis due to rapid relapse after an initial treatment response. More effective treatments for SCLC are desperately needed. Our previous studies showed that cell migration-inducing hyaluronan binding protein (CEMIP) functionally promotes SCLC cell proliferation and metastasis. In this study, we investigated whether and how CEMIP regulates the chemosensitivity of SCLC. Through the GDSC database, we found that CEMIP expression levels were positively correlated with the IC

Indexed as

Adaptor Proteins, Signal TransducingAntineoplastic AgentsLung NeoplasmsMice, NudeSmall Cell Lung Carcinomasrc-Family KinasesTranscription FactorsYAP-Signaling ProteinsAnimalsCell Line, TumorCell ProliferationCisplatinDrug Resistance, NeoplasmEtoposideHumansMiceAdaptor Proteins, Signal TransducingAntineoplastic AgentsCisplatinEtoposidesrc-Family KinasesTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsadaptor proteinCEMIPchemotherapy sensitivitysmall cell lung cancerSRCYAP

Identifiers

PMID39043968
PMCPMC11579373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.