Evidence map›Paper›PMID 39043843›Full record

ArticleMolecular psychiatry2025

Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer's disease mice.

Thomas A Kim, George Cruz, Michelle D Syty, Faye Wang, Xinxing Wang, Alexandra Duan, Marc Halterman, Qiaojie Xiong, Jorge J Palop, Shaoyu Ge

Abstract read
In one paragraph

Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Characterization of adult hippocampal neurogenesis in the novelbioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas A KimMedical Scientist Training Program (MSTP), Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0002-9244-2329
George CruzProgram in Neuroscience, Stony Brook University, Stony Brook, NY, 11794, USA.
Michelle D SytyDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.
Faye WangDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.
Xinxing WangDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.
Alexandra DuanDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA.
Marc HaltermanDepartment of Neurology, Stony Brook University, Stony Brook, NY, 11794, USA.
Qiaojie XiongDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA. qiaojie.xiong@stonybrook.edu.ORCID 0000-0002-9221-860X
Jorge J PalopGladstone Institute of Neurological Disease, San Francisco, CA, 94158, USA. jorge.palop@gladstone.ucsf.edu.
Shaoyu GeDepartment of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY, 11794, USA. shaoyu.ge@stonybrook.edu.ORCID 0000-0002-5744-605X

Funding

Project 4: Cross-species Dissection of Cellular Response to APOE Genotype and AD Pathology Using Single-cell Multi-omicsP01AG073082 · NIA · J. DAVID GLADSTONE INSTITUTES · PI HUANG, YADONG, MUCKE, LENNART · 2021 to 2025
$23.4M
Multidimensional mapping of vulnerable cell types in humanized Alzheimer's disease mouse modelsR01AG082147 · NIA · STANFORD UNIVERSITY · PI Inma Cobos, Jorge J Palop · 2023 to 2026
$9.3M
Deciphering molecular pathways of inhibitory interneuron dysfunction in Alzheimer's diseaseR01AG062629 · NIA · J. DAVID GLADSTONE INSTITUTES · PI PALOP, JORGE J · 2019 to 2023
$3.6M
Integration of the thalamic and cortical inputs in the auditory striatumR01DC017470 · NIDCD · STATE UNIVERSITY NEW YORK STONY BROOK · PI XIONG, QIAOJIE · 2019 to 2023
$2.4M
Mechanistic study of declining hippocampal neurogenesis in the aging brainR01AG066912 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI GE, SHAOYU, XIONG, QIAOJIE · 2020 to 2024
$2.0M
The Role of Striatal Neurovascular Coupling in LearningR21NS130508 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI XIONG, QIAOJIE · 2023 to 2023
$432k
Dynamic neurovascular coupling in activity-induced hippocampal neurogenesisR21AG065864 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI GE, SHAOYU · 2020 to 2021
$360k
NIA NIH HHS P01 AG073082NIA NIH HHS R01 AG062629NIA NIH HHS R01 AG066912NIA NIH HHS R01 AG082147NIA NIH HHS R21 AG065864NIDCD NIH HHS R01 DC017470NINDS NIH HHS R21 NS130508U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P01AG073082U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG066912U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) R01AG0821471
6 · The paper itself

Abstract

Neurovascular defects are one of the most common alterations in Alzheimer's disease (AD) pathogenesis, but whether these deficits develop before the onset of amyloid beta (Aβ) accumulation remains to be determined. Using in vivo optical imaging in freely moving mice, we explored activity-induced hippocampal microvascular blood flow dynamics in App

Indexed as

Alzheimer DiseaseHyperemiaAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsCerebrovascular CirculationDisease Models, AnimalHippocampusInterneuronsMaleMiceMice, Inbred C57BLMice, TransgenicNeuronsNeurovascular CouplingNitric OxideAmyloid beta-PeptidesAmyloid beta-Protein PrecursorNitric Oxide

Identifiers

PMID39043843
PMCPMC11750623

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.